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Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
Brain Research Reviews, 2008Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug dependence may substantially build on the existence of intramembrane receptor-receptor interactions within dopamine receptor containing receptor mosaics (RM; dimeric or high-order receptor oligomers ...
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Receptor Regulation and Receptor-Receptor Communication
1987As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations.
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Cellular and Molecular Life Sciences, 2008
Glucagon is a pancreatic peptide hormone that, as a counterregulatory hormone for insulin, stimulates glucose release by the liver and maintains glucose homeostasis. First described as a glucagon binding entity functionally linked to adenylyl cyclase, the glucagon receptor is a member of the family B receptors within the G protein coupled superfamily ...
Authier, François, Desbuquois, Bernard
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Glucagon is a pancreatic peptide hormone that, as a counterregulatory hormone for insulin, stimulates glucose release by the liver and maintains glucose homeostasis. First described as a glucagon binding entity functionally linked to adenylyl cyclase, the glucagon receptor is a member of the family B receptors within the G protein coupled superfamily ...
Authier, François, Desbuquois, Bernard
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Science, 2008
Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Current Opinion in Immunology, 1991
In the past year, significant progress in the area of Fc receptor biology has been made in three areas: identification of the protective FcR for serum IgG half-life (Brambell receptor), characterization of the mechanism(s) of inhibitory receptor Fc gamma RIIB signaling, and dissection of the in vivo roles of FcRs in inflammation.
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In the past year, significant progress in the area of Fc receptor biology has been made in three areas: identification of the protective FcR for serum IgG half-life (Brambell receptor), characterization of the mechanism(s) of inhibitory receptor Fc gamma RIIB signaling, and dissection of the in vivo roles of FcRs in inflammation.
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Pharmaceutica Acta Helvetiae, 2000
The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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The thyrotropin receptor as a model to illustrate receptor and receptor antibody diseases
Baillière's Clinical Endocrinology and Metabolism, 1995The thyrotropin receptor (TSHR) has been used as an example to illustrate how disease may be the consequence of: 1. Modifications or inappropriate production of the natural ligand. 2. Production of abnormal agonists or antagonists such as autoantibodies. 3.
Ludgate, Marian, Vassart, Gilbert
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Bradykinin receptors and receptor ligands (with special emphasis on vascular receptors)
Regulatory Peptides, 1996Bradykinin and receptor ...
REGOLI, Domenico +7 more
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Receptor‐Receptor Interactions and Their Relevance for Receptor Diversity
Annals of the New York Academy of Sciences, 1995Receptor diversity in combination with receptor-receptor subtype specific interactions, which can be antagonistic or synergistic in character, markedly increase plasticity in WT and VT in the nervous system. In this way switching among transmission lines for the various DA receptor subtypes becomes possible.
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Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function
2018The melatonin receptor subfamily is composed of three members, MT1 and MT2, which are binding to melatonin, and GPR50, which shows high sequence homology to MT1 and MT2 but does not bind to melatonin or any other known ligand. An interesting feature of these receptors is their capacity to form homo- and heteromers between each other and also with other
Atsuro, Oishi +2 more
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