Results 61 to 70 of about 141,931 (309)
Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]
PLoS ONE, 2012 The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea +4 more
doaj +1 more source
Alpha-1-Adrenergic receptors as new targets in Neuroblastoma
, 2021 High-risk neuroblastoma (NB) is an aggressive childhood tumor that originates from progenitor neural crest cells. Even if the therapeutic protocol for NB is articulate and aggressive, the outcome remains dismal, with the 5-year disease-free overall survival below rating 50%.
openaire +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2014 Transcutaneous electrical nerve stimulation (TENS) is a type of therapy used primarily for analgesia, but also presents changes in the cardiovascular system responses; its effects are dependent upon application parameters.
O.S. Franco +8 more
doaj +1 more source
Alpha‐1 adrenergic receptor regulation of seizures and neurodegeneration
The FASEB Journal, 2008 Neurogenesis has potential as a treatment for epilepsy and neurodegeneration. The endogenous neurotransmitter norepinephrine (NE) may be involved in promoting neurogenesis through the activation of α 1 adrenergic receptors (ARs).
Brianna Goldenstein +6 more
openaire +1 more source
Advanced Science, EarlyView.A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang +10 more
wiley +1 more source
MGM Journal of Medical Sciences, 2019 Background: Stent-related symptoms affect nearly 80% of patients with indwelling ureteral stents. Alpha blockers relieve flank pain by blocking alpha-adrenergic receptors and relaxing the smooth muscles of ureter, trigone, and prostatic urethra, thus ...
Abhay Mahajan, Dhruti Amlani
doaj +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Journal of Biological Chemistry, 1992 High efficiency transient transfection of Cos-7 cells was previously used to establish the functional coupling between G alpha q/G alpha 11 and phospholipase C beta 1 (Wu, D., Lee, C-H., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 1811-1817).
Dianqing Wu +3 more
semanticscholar +1 more source
Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity
Advanced Science, EarlyView.Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau +22 more
wiley +1 more source