Results 221 to 230 of about 25,910 (235)

Pharmacological Evidence for the Heterogeneity of Atrial Natriuretic Factor-R1 Receptor Subtype

Molecular Pharmacology, 1991
The atrial natriuretic factor-R1 (ANF-R1) receptor is known to mediate the biological effects of diverse natriuretic/diuretic/vasorelaxant peptides. In order to investigate the differential selectivity of this class of receptor, we have compared its pharmacological profile for various natriuretic peptides in rat, bovine, and human kidney.
J, Féthière, A, De Léan
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ATP-regulated module (ARM) of the atrial natriuretic factor receptor guanylate cyclase

Peptides, 2005
ATP is an obligatory agent for the atrial natriuretic factor (ANF) and the type C natriuretic peptide (CNP) signaling of their respective receptor guanylate cyclases, ANF-RGC and CNP-RGC. Through a common mechanism, it binds to a defined ARM domain of the cyclase, activates the cyclase and transduces the signal into generation of the second messenger ...
Teresa, Duda, Venkateswar, Venkataraman, Sarangan, Ravichandran, Rameshwar K, Sharma   +3 more
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Molecular characteristics of receptors for atrial natriuretic factor.

Federation proceedings, 1986
Specific, high-affinity receptors for atrial natriuretic factor (ANF) have been identified on membranes from a variety of tissues and cultured cells. By affinity labeling procedures, radioactivity from 125I-labeled ANF was specifically incorporated into three different polypeptides of ca.
R L, Vandlen, K E, Arcuri, L, Hupe, M E, Keegan, M A, Napier   +4 more
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Hemodynamic Effects of Atrial Natriuretic Factor Clearance Receptor Occupancy in Conscious Sheep

American Journal of Hypertension, 1990
The present study examined the hemodynamic actions of a non-guanylate cyclase linked or "clearance" atrial natriuretic factor (ANF) receptor ligand--des[Gln116Ser117Gly118Leu119Gly120] ANF 102-121 (C-ANF 4-23)--in conscious sheep. The effect of this peptide on the duration and potency of the hypotensive action of ANF (99-126) was also studied. C-ANF (4-
D G, Parkes, J P, Coghlan, J A, Lewicki, R M, Scarborough, B A, Scoggins   +4 more
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Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure

American Journal of Physiology-Heart and Circulatory Physiology, 1993
Atrial natriuretic factor (ANF) is a circulating 28-amino acid peptide that functions in the regulation of sodium homeostasis and vascular tone. ANF metabolism occurs via degradation by neutral endopeptidase 24.11 and binding to the ANF clearance receptor (ANFR-C).
M A, Perrella, L L, Aarhus, D M, Heublein, J A, Lewicki, J C, Burnett   +4 more
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High-Yield Affinity Alkylation of the Atrial Natriuretic Factor Receptor Binding Site

Bioconjugate Chemistry, 1995
To facilitate characterization of the atrial natriuretic factor (ANF) receptor, we have developed an affinity labeling procedure, stepwise affinity labeling, which allows specific labeling of ANF binding sites in adrenal plasma membranes at high yields.
X, He, K, Nishio, K S, Misono
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Characterization of receptors for the atrial natriuretic factor in rat renal microvessels

Journal of Hypertension, 1993
To characterize [125I]-atrial natriuretic factor [ANF-(99-126)] binding sites in the renal preglomerular microvasculature of Sprague-Dawley rats.Renal preglomerular microvessels were isolated by infusion of a magnetized iron oxide solution into the renal arteries and detachment from non-vascular tissue by a magnetic field.
H, De León, G, Gauquelin, G, Thibault, R, Garcia   +3 more
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Pharmacology and Receptor Binding of Atrial Natriuretic Factor in Vascular Smooth Muscle

Clinical and Experimental Hypertension. Part A: Theory and Practice, 1985
Characterization of the vascular pharmacology and receptor binding of atrial natriuretic factor (ANF) has been achieved utilizing a synthetic peptide which contains the sequence and biological activity of ANF. The synthetic ANF (sANF) relaxes aortic segments contracted by agonists or by low (15 to 20 mM) but not high (greater than or equal to 40 mM ...
R J, Winquist, M A, Napier, R L, Vandlen, K, Arcuri, M E, Keegan, E P, Faison, E P, Baskin   +6 more
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Development of natriuretic peptide analogs selective for the atrial natriuretic factor-R1A receptor subtype.

Molecular Pharmacology, 1993
A pharmacological characterization of subtypes of the atrial natriuretic factor (ANF) receptor ANF-R1, found in bovine adrenal cortex and rat papillary membrane preparations, has been carried out using various chimeric analogs based on rat ANF(99-126) [rANF(99-126)] and porcine brain natriuretic peptide 32 (pBNP32). Receptor binding and cGMP production
M, Mimeault, A, Fournier, J, Féthiere, A, De Léan   +3 more
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In vitro secretion of atrial natriuretic factor: receptor-mediated release of prohormone

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1988
Secretion of atrial natriuretic factor (ANF) in vivo is thought to be mediated by atrial distension. We have shown previously that nonstretched atria can release natriuretic activity in vitro when stimulated by certain agonists. In the present study atrial appendages from freshly excised rat hearts were incubated at 37 degrees C for up to 1 h in the ...
A T, Veress, S, Milojevic, C, Yip, T G, Flynn, H, Sonnenberg   +4 more
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