Results 21 to 30 of about 2,926,869 (253)

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background A hallmark of heart failure is cardiac fibrosis, which results from the injury‐induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix.
Nicholas W. Chavkin, Soichi Sano, Ying Wang, Kosei Oshima, Hayato Ogawa, Keita Horitani, Miho Sano, Susan MacLauchlan, Anders Nelson, Karishma Setia, Tanvi Vippa, Yosuke Watanabe, Jeffrey J. Saucerman, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh   +15 more
doaj   +1 more source

Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors

International Journal of Molecular Sciences, 2014
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins belonging to a large family of cell-surface receptors involved in many intracellular signaling cascades.
F. Cattaneo, G. Guerra, Melania Parisi, Marta De Marinis, D. Tafuri, M. Cinelli, R. Ammendola   +6 more
semanticscholar   +1 more source

A generic cell surface ligand system for studying cell-cell recognition.

PLoS Biology, 2019
Dose-response experiments are a mainstay of receptor biology studies and can reveal valuable insights into receptor function. Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating the surface ...
Eleanor M Denham, Michael I Barton, Susannah M Black, Marcus J Bridge, Ben de Wet, Rachel L Paterson, P Anton van der Merwe, Jesse Goyette   +7 more
doaj   +1 more source

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy

Cancer Cell International, 2022
Background Immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized cancer therapy. However, therapeutic targeting of inhibitory T cell receptors such as PD-1 not only initiates a broad immune response against tumors, but also causes ...
Simon Heumos, Sandra Dehn, Konstantin Bräutigam, Marius C. Codrea, Christian M. Schürch, Ulrich M. Lauer, Sven Nahnsen, Michael Schindler   +7 more
doaj   +1 more source

Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19

Biomolecules, 2021
The Ig fold has had a remarkable success in vertebrate evolution, with a presence in over 2% of human genes. The Ig fold is not just the elementary structural domain of antibodies and TCRs, it is also at the heart of a staggering 30% of immunologic cell ...
Philippe Youkharibache
doaj   +1 more source

Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles

Journal of Physical Chemistry B, 2014
Nanoparticles used for biological and biomedical applications encounter a host of extracellular proteins. These proteins rapidly adsorb onto the nanoparticle surface, creating a protein corona.
C. Fleischer, C. Payne
semanticscholar   +1 more source

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]

, 2017
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R, Paolini, R., Quatrini, L, Santoni, A   +3 more
core   +2 more sources

Cell-surface translational dynamics of nicotinic acetylcholine receptors

Frontiers in Synaptic Neuroscience, 2014
Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic ...
Francisco J Barrantes
doaj   +1 more source