Results 81 to 90 of about 743,802 (291)

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF

eLife, 2014
Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Guo Cheng, Ming Zhong, Riki Kawaguchi, Miki Kassai, Muayyad Al-Ubaidi, Jun Deng, Mariam Ter-Stepanian, Hui Sun   +7 more
doaj   +1 more source

Guanylate Cyclase, a Cell Surface Receptor

Journal of Biological Chemistry, 1989
Guanylate cyclase appears to represent a central member of a diverse family of proteins involved in cell signaling mechanisms including the protein kinases, a low Mr ANP receptor, and possibly adenylate cyclase (based on limited sequence identity with the yeast enzyme).
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Mobility of cell surface receptors: a re‐evaluation

FEBS Letters, 1998
It has long been known from fluorescence recovery after photobleaching experiments that the mobility of most cell surface receptors is much smaller than expected for free diffusion of proteins in a fluid lipid bilayer. Single‐particle tracking experiments are currently revealing the complexity of the constraints to free diffusion.
Cherry, Richard J, Smith, Patricia R, Morrison, Ian E.G, Fernandez, Nelson   +3 more
openaire   +2 more sources

Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration [PDF]

, 1996
In search of synthetic high affinity ligands for the mannose receptor, we synthesized a series of lysine-based oligomannosides containing two (M2L) to six (M6L5) terminal α-D-mannose groups that are connected with the backbone by flexible elongated ...
Teijlingen, M.E. van, Kuiper, J., Berkel, T.J.G. van, Bijsterbosch, M.K., Barrett-Bergshoeff, M.M., Rijken, D.G., Biessen, E.A.L., Noorman, F.   +7 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Interaction of Viruses with Cell Surface Receptors

, 1982
This chapter discusses the interaction of viruses with cell surface receptors. The rigorous characterizations of receptor–ligand interactions have been derived from binding studies of radiolabeled ligands in neuropharmacology and endocrinology. The definition of viral recognition sites as receptors involves three major criteria that are derived from ...
Tardieu, Marc, Epstein, Rochelle L., Weiner, Howard L.   +2 more
openaire   +2 more sources

Cysteine-rich Receptor-like Kinase 7 functions as a receptor for Wall Teichoic Acid, a MAMP specific for gram-positive bacteria with non-canonical activities in Arabidopsis thaliana [PDF]

Plants are constantly surrounded by a plethora of microorganisms, including fungi, oomycetes, and bacteria. To sense their presence and distinguish between different kinds of microbes, plants utilize a variety of cell-surface receptors, sensing Microbe ...
Pierdzig, Leon
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source