Results 111 to 120 of about 1,154,493 (312)

Beta-Adrenergic Receptor Blockade By Propranolol Enhances Retention In A Multitrial Passive-Avoidance Procedure [PDF]

, 2000
The effect of beta -adrenergic receptor blockade on retention in a mildly aversive passive-avoidance procedure was investigated. Rats were given passive-avoidance training-1 trial per day for 4 days-and were administered saline, the centrally and ...
Koven, Nancy, , \u2798, Levin, Dimitriy A., , \u2701, Lombardo, Kimberly A., , \u2798, Schneider, Allen M., Simson, Peter E., , \u2778   +4 more
core   +1 more source

Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study. [PDF]

, 2020
As perspectives on cannabis continue to shift, understanding the physiological and behavioral effects of cannabis use is of paramount importance. Previous data suggest that cannabis use influences food intake, appetite, and metabolism, yet human research
Abulseoud, Osama A, Farokhnia, Mehdi, Huestis, Marilyn A, Leggio, Lorenzo, McDiarmid, Gray R, Munjal, Vikas, Newmeyer, Matthew N   +6 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors

Molecules, 2015
The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death.
Tahsin F. Kellici, Andreas G. Tzakos, Thomas Mavromoustakos   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Genetic inference of on-target and off-target side-effects of antipsychotic medications.

PLoS Genetics
It is often difficult to ascertain whether patient-reported side-effects are caused by a drug, and if so, through which mechanism. Adverse side-effects are the primary cause of antipsychotic drug discontinuation rather than poor efficacy.
Andrew R Elmore, Aws Sadik, Lavinia Paternoster, Golam M Khandaker, Tom R Gaunt, Gibran Hemani   +5 more
doaj   +1 more source

Progress in structure-based drug development targeting chemokine receptors

Frontiers in Pharmacology
As a critical subfamily of G protein-coupled receptors (GPCRs), chemokine receptors (CCRs) play pivotal regulatory roles in immune cell migration, inflammatory modulation, tissue regeneration, and tumor microenvironment (TME) remodeling.
Jin Wang, Chen Qu, Peng Xiao, Sijin Liu, Jin-Peng Sun, Yu-Qi Ping   +5 more
doaj   +1 more source

Solubilization and Display of G Protein-Coupled Receptors on Beads for Real-Time Fluorescence and Flow Cytometric Analysis

BioTechniques, 2000
G protein-coupled receptors (GPCR) and cellular signaling elements are prime targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities for these elements can play significant roles in basic research and drug discovery.
L.A. Sklar, J. Vilven, E. Lynam, D. Neldon, T.A. Bennett, E. Prossnitz   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Understanding Nicotine Addition: Dependency as a Result of Maladaptive Brain Structure [PDF]

, 2014
Nicotine addiction is the most prevalent, destructive dependency found in our culture. Despite its well-documented damaging health risks, nicotine use is still widely accepted and could be conceptualized as a social epidemic.
Thomas, Nate
core   +1 more source