Results 261 to 270 of about 45,803 (309)

Different domains of the glucagon and glucagon‐like peptide‐1 receptors provide the critical determinants of ligand selectivity

British Journal of Pharmacology, 2003
(1) Glucagon and glucagon-like peptide-1 (GLP-1) are homologous peptide hormones with important functions in glucose metabolism. The receptors for glucagon and GLP-1 are homologous family B G-protein coupled receptors.
Hans Brauner-Osborne, Lotte Bjerre Knudsen   +1 more
exaly   +2 more sources

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Structure of the glucagon receptor in complex with a glucagon analogue

Nature, 2018
Class B G-protein-coupled receptors (GPCRs), which consist of an extracellular domain (ECD) and a transmembrane domain (TMD), respond to secretin peptides to play a key part in hormonal homeostasis, and are important therapeutic targets for a variety of diseases.
Haonan, Zhang, Anna, Qiao, Linlin, Yang, Ned, Van Eps, Klaus S, Frederiksen, Dehua, Yang, Antao, Dai, Xiaoqing, Cai, Hui, Zhang, Cuiying, Yi, Can, Cao, Lingli, He, Huaiyu, Yang, Jesper, Lau, Oliver P, Ernst, Michael A, Hanson, Raymond C, Stevens, Ming-Wei, Wang, Steffen, Reedtz-Runge, Hualiang, Jiang, Qiang, Zhao, Beili, Wu   +21 more
openaire   +2 more sources

Increase of glucagon receptors in hyperthyroidism

Nature, 1976
THYROID hormones influence the lipolytic response of rat adipocytes to adrenaline, glucagon, ACTH and TSH1,2. Krishna, Hynie and Brodie3 provided evidence that hyperthyroidism is followed by an increase in the nor-adrenaline-sensitive adenylate cyclase without any change in phosphodiesterase activity. Subsequent investigations have shown that adenylate
S N, Madsen, O, Sonne
openaire   +2 more sources

Amino acids are sensitive glucagon receptor‐specific biomarkers for glucagon‐like peptide‐1 receptor/glucagon receptor dual agonists

Diabetes, Obesity and Metabolism, 2020
Abstract Aim The aim of this study was to evaluate amino acids as glucagon receptor (GCGR)‐specific biomarkers in rodents and cynomolgus monkeys in the presence of agonism of both glucagon‐like peptide‐1 receptor (GLP1R) and GCGR with a variety of dual agonist compounds.
Wenyu Li, Thomas Kirchner, George Ho, Fany Bonilla, Katharine D'Aquino, James Littrell, Rui Zhang, Wenying Jian, Xi Qiu, Songmao Zheng, Bin Gao, Peggy Wong, James N. Leonard, Raul C. Camacho   +13 more
openaire   +2 more sources

Characterization of the Glucagon Receptor in a Pheochromocytoma

The Journal of Clinical Endocrinology & Metabolism, 1975
Glucagon activated adenylate cyclase in a homogenate of a pheochromocytoma over the concentration range 1 times 10 minus 8M to 1 times 10 minus 6M. Several other hormones including adrenocorticotropin, thyrotropin, parathyroid hormone and histamine were without effect.
G S, Levey, S R, Weiss, E, Ruiz
openaire   +2 more sources

Characterization of the Hepatic Glucagon Receptor

Journal of Receptor Research, 1984
The hepatic glucagon receptor was covalently labeled with [125I-Tyr10]-monoiodoglucagon by use of the heterobifunctional crosslinker hydroxysuccinimidyl-p-azidobenzoate and analyzed by SDS-gel electrophoresis. The autoradiogram of the gel showed one band at Mr = 63,000 that was sensitive to excess unlabeled glucagon and GTP.
R, Iyengar, J T, Herberg, K A, Rich
openaire   +2 more sources

Glucagon and Glucagon-Like Peptide Receptors as Drug Targets

Current Pharmaceutical Design, 2006
Glucagon and the glucagon-like peptides are derived from a common proglucagon precursor, and regulate energy homeostasis through interaction with a family of distinct G protein coupled receptors. Three proglucagon-derived peptides, glucagon, GLP-1, and GLP-2, play important roles in energy intake, absorption, and disposal, as elucidated through studies
J L, Estall, D J, Drucker
openaire   +2 more sources

Role of the Glucagon Receptor COOH-Terminal Domain in Glucagon-Mediated Signaling and Receptor Internalization

Diabetes, 1997
The binding of glucagon to its hepatic receptor is known to result in a number of effects, including the intracellular accumulation of cAMP, the mobilization of intracellular Ca2+, and the endocytosis of glucagon and its receptor into intracellular vesicles.
J J, Buggy, R O, Heurich, M, MacDougall, K A, Kelley, J N, Livingston, H, Yoo-Warren, A J, Rossomando   +6 more
openaire   +2 more sources

The glucagon receptor and adenylate cyclase

Metabolism, 1975
Acidic phospholipids play a critical role in the hormone activation of adenylate cyclase. Solubilized myocardial adenylate cyclase is unresponsive to glucagon and the catecholamines, two of the hormones which activate the membrane-bound enzyme. Phosphatidylserine, purified from bovine brain restored glucagon responsiveness of the solubilized adenylate ...
openaire   +2 more sources

Human Glucagon Receptor Monoclonal Antibodies: Antagonism of Glucagon Action and Use in Receptor Characterization

Hormone and Metabolic Research, 1996
This paper describes the development and characterization of the first monoclonal antibody specific for the recently cloned human glucagon receptor (hGR), and its use in probing receptor structure and function. We demonstrate specificity of one of the antibodies, CIV395.7A, by immunofluorescence staining and immunoprecipitation analysis.
J, Buggy, A, Rossomando, M, MacDougall, D, Mierz, D, Wunderlich, H, Yoo-Warren   +5 more
openaire   +2 more sources