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Histamine Receptors in the Lung
Allergy and Asthma Proceedings, 1987The availability of specific histamine receptor antagonists has provided evidence that human airways have both H1 and H2 receptors. H1 receptors, which mediate bronchoconstriction, predominate. H1 receptor antagonism can produce significant bronchodilatation in some asthmatics, block bronchoconstriction induced by antigen and histamine inhalation ...
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Histamine Receptors in the Lung
1991Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. H1-receptors mediate bronchoconstriction, vasoconstriction and dilatation, microvascular leak and activation of sensory nerves.
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Histamine receptors are hot in immunopharmacology
European Journal of Pharmacology, 2006In addition to its well-characterized effects in the acute allergic inflammatory responses, histamine has been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. Histamine can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and ...
Cezmi A, Akdis, F Estelle R, Simons
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The new biology of histamine receptors
Current Allergy and Asthma Reports, 2008The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histamine compared with the histamine H1 ...
Jing-Feng, Huang, Robin L, Thurmond
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Histamine H3 Receptor Agonists
Mini-Reviews in Medicinal Chemistry, 2004The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
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Histamine H4 receptor agonists
Bioorganic & Medicinal Chemistry Letters, 2010Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of inflammatory and allergic diseases. Potent and selective ligands including agonists are required as pharmacological tools to study the role of the H(4)R in vitro and in vivo.
Patrick, Igel +2 more
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Histamine Receptors in the Synovial Microcirculation
European Journal of Clinical Investigation, 1975Abstract. This study was designed to investigate the respective roles of H1 and H2 receptors in the control of the microcirculation by examining the effectiveness of the H2 receptor antagonist metiamide (Met.) and Hj receptor antagonist mepyramine is blocking the action of histamine on synovial perfusion. Synovial perfusion was monitored indirectly by
D. M. Grennan +5 more
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2002
Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Histamine H3-receptor isoforms
Inflammation Research, 2004Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor.
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