Results 91 to 100 of about 41,179 (270)

Multimodal spatial gradients to explain regional susceptibility to fibrillar tau in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION In Alzheimer's disease (AD), fibrillar tau gradually progresses from initial seed to larger brain area. However, those brain properties underlying the region‐dependent susceptibility to tau accumulation remain unclear. METHODS We constructed multimodal spatial gradients to characterize molecular properties and connectomic ...
Ying Luan, Lukai Zheng, Jannis Denecke, Amir Dehsarvi, Sebastian N. Roemer‐Cassiano, Anna Dewenter, Anna Steward, Sergey Shcherbinin, Diana Otero Svaldi, Vikas Kotari, Ixavier Alonzo Higgins, Michael J. Pontecorvo, Carolina Valentim, Julia A. Schnabel, Francesco Paolo Casale, Martin Dyrba, Stefan Teipel, Nicolai Franzmeier, Michael Ewers, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +19 more
wiley   +1 more source

Effect of histamine on the electric activities of cerebellar Purkinje cell [PDF]

arXiv, 1999
The effect of histamine (HA) on the electric activities of Purkinje cell (PC) is studied on the cerebellum slice. We find that: (1) HA's main effect on PC is excitative (72.9%); there are also a small amount of PC showing inhibitive (10.2%) or no (16.9%) response to HA.
arxiv  

Angelica dahurica Polysaccharides Ameliorate Colitis by Reducing the Restriction of Gut Microbiota‐Derived Imidazole Propionate on PPAR‐γ Signaling Activation

Phytotherapy Research, Volume 39, Issue 5, Page 2072-2090, May 2025.
ABSTRACT Angelica dahurica radix (ADR), the root of the botanical family Apiaceae (genus Angelica, species Angelica dahurica (Hoffm.)), has been used to treat colitis in clinical practice. The immunomodulatory effects of ADR are attributed to its polysaccharides (RP). However, its mechanism of action has not been elucidated.
Jingyi Hu, Feng Xu, Lei Zhu, Yuan Cui, Ryan Au, Yanan Li, Yiheng Tong, Hong Shen   +7 more
wiley   +1 more source

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

Frontiers in Pharmacology, 2017
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
A. Alachkar, D. Łażewska, K. Kieć‐Kononowicz, B. Sadek   +3 more
semanticscholar   +1 more source

Cellular distribution of the histamine H3 receptor in the basal ganglia : functional modulation of dopamine and glutamate neurotransmission [PDF]

, 2013
This is the author's version of a work that was accepted for publication in Basal ganglia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Castillo Ruiz, Mª del Mar, Díaz, Jorge, González Sepúlveda, Marta, Hoffmann, Hanne Mette, Mignon, Virginie, Moreno Delgado, David, Ortiz de Pablo, Jordi, Rosell Vilar, Santi, Sabrià i Pau, Josefa, Vignes, Michel   +9 more
core   +2 more sources

Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats [PDF]

Veterinary Research Forum, 2010
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 µl, 2.5 %)
Emad Khalilzadeh, Esmaeal Tamaddonfard, Amir-Abbas Farshid, Amir Erfanparast   +3 more
doaj  

Prospects of using Antagonist Histamine H2-Receptor (Cimetidinum) as Adjuvant for Melanoma Biotherapy Treatment [PDF]

International Journal of Immunopathology, Allergology, Infectology 2010, #4: P. 42-51, 2011
Improvement of anti-tumor biotherapy effectiveness by modification of immune response with histamine H2 receptor Cimetidinum (CM) was studied using the experimental murine model of B16 F10 melanoma in vivo. It is shown that skin melanoma biotherapy by antitumor whole-cell GM-CSF-producing vaccine with the addition of CM (in dose of 25 mg/kg, daily for ...
arxiv  

Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

eLife, 2020
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death.
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick   +17 more
doaj   +1 more source

Molecular Regulation of Histamine Synthesis [PDF]

arXiv, 2018
Histamine is a critical mediator of IgE/ cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine.
arxiv