Results 101 to 110 of about 41,179 (270)

Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists

Behavioural Pharmacology, 2014
To determine the potential of histamine H3 receptor (H3R) ligands as new antiepileptic drugs (AEDs), aromatic ether, and diether derivatives (1-12) belonging to the nonimidazole class of ligands, with high in-vitro binding affinity at human H3R, were tested for their in-vivo anticonvulsive activity in the maximal electroshock (MES)-induced and ...
Sadek, Bassem, Kuder, Kamil, Subramanian, Dhanasekaran, Shafiullah, Mohamed, Stark, Holger, Łażewska, Dorota, Adem, Abdu, Kieć-Kononowicz, Katarzyna   +7 more
openaire   +4 more sources

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Computational pipeline to identify potential drug targets and pathways for Rett syndrome, by analyzing ligand‐bound pockets and predicted drug affinities. ABSTRACT Rett syndrome (RTT) is a progressive neurodevelopmental disorder that affects approximately 1:10000 newborn girls and is primarily caused by mutations in the X‐linked gene MECP2.
Ottavia Maria Roggero, Nicolò Gualandi, Viviana Ciraci, Vittoria Berutto, Emanuele Carosati, Enrico Tongiorgi   +5 more
wiley   +1 more source

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

PLoS ONE, 2017
The crucial role of G-protein coupled receptors and the significant achievements associated with a better understanding of the spatial structure of known receptors in this family encouraged us to undertake a study on the histamine H3 receptor, whose ...
Jakub Jończyk, B. Malawska, M. Bajda
semanticscholar   +1 more source

Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice [PDF]

, 2015
Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ejtemaie Mehr, Shahram., Gooshe, Maziar., Haj-Mirzaian, Arya., Hassanipour, Mahsa., Rahimi-Balaei, Maryam., Shirzadian, Armin.   +9 more
core  

Sites of action of sleep and wake drugs: insights from model organisms [PDF]

, 2013
Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core   +1 more source

Typical and Atypical Antipsychotic Drugs Increase Extracellular Histamine Levels in the Rat Medial Prefrontal Cortex: Contribution of Histamine H1 Receptor Blockade

Frontiers in Psychiatry, 2012
Atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics.
Kjell A Svensson
doaj   +1 more source

The Crosstalk with CXCL10‐Rich Tumor‐Associated Mast Cells Fuels Pancreatic Cancer Progression and Immune Escape

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Pancreatic cancer promotes the accumulation of mast cells in the tumor microenvironment. Tumor‐derived exosomes deliver miR‐188‐5p to tumor‐associated mast cells (TAMCs), enhancing TAMCs‐derived CXCL10 secretion by strengthening ERG transcription. TAMCs‐derived CXCL10 promotes tumor migration, stemness, and immunosuppressive environment.
Hanlin Yin, Qiangda Chen, Shanshan Gao, Sami Shoucair, Yuqi Xie, Joseph R. Habib, Taochen He, Wei Gan, Juan Wang, Lei Zhang, Huaxiang Xu, Chenye Shi, Junyi He, Wenquan Wang, Yun Jin, Michael G Goggins, Liang Liu, Wenhui Lou, Wenchuan Wu, Jun Yu, Ning Pu   +20 more
wiley   +1 more source

Effects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on ...
Esmaeal Tamaddonfard, Nasrin Hamzeh Gooshchi   +1 more
doaj  

Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer. [PDF]

PLoS ONE, 2014
We previously found that genetic polymorphisms in gene coding for histamine H4 receptors were related to the risk and malignant degree of breast cancer.
Gong-Hao He, Jia-Ji Lin, Wen-Ke Cai, Wen-Mang Xu, Zheng-Ping Yu, Sun-Jun Yin, Can-Hu Zhao, Gui-Li Xu   +7 more
doaj   +1 more source

Glaucoma animal models in rabbits: State of the art and perspectives—A review

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 429-440, March 2025.
Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma.
Rong Hu, Kai Wu, Jian Shi, Juan Yu, Xiao‐lei Yao   +4 more
wiley   +1 more source