Results 111 to 120 of about 41,179 (270)
Brain and Behavior, Volume 15, Issue 3, March 2025.The aim of the present study was to evaluate the anxiolytic and analgesic effects of the water extract of P. africanum on autistic triad induced in rats with sodium valproate. Pregnant female rats were given sodium valproate at 800 mg/kg during gestation.
Ambani Omgba Jeanne Julie +10 more
wiley +1 more source
Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists
Drug Design, Development and Therapy, 2016 Phenytoin (PHT), valproic acid, and modern antiepileptic drugs (AEDs), eg, remacemide, loreclezole, and safinamide, are only effective within a maximum of 70%–80% of epileptic patients, and in many cases the clinical use of AEDs is restricted by their ...
B. Sadek +5 more
semanticscholar +1 more source
Efficient and Robust Long-Form Speech Recognition with Hybrid H3-Conformer [PDF]
Recently, Conformer has achieved state-of-the-art performance in many speech recognition tasks. However, the Transformer-based models show significant deterioration for long-form speech, such as lectures, because the self-attention mechanism becomes unreliable with the computation of the square order of the input length.
arxiv +1 more source
Human Brain Mapping, Volume 46, Issue 4, March 2025.The observed decrease in cerebral blood flow (CBF) in the left putamen could potentially serve as a neural biomarker for chronic insomnia disorder, while acupuncture may alleviate insomnia symptoms by increasing CBF in this region, potentially through the modulation of GABAa and D1 receptor expressions.
Liyong Yu +11 more
wiley +1 more source
Low Brain Histamine Content Affects Ethanol-Induced Motor Impairment
Neurobiology of Disease, 2002 The effect of ethanol on motor performance in humans is well established but how neural mechanisms are affected by ethanol action remains largely unknown.
Minnamaija Lintunen +8 more
doaj
Frontiers in Immunology, 2017 Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease where activated glia release pro-inflammatory cytokines that trigger a vicious cycle of neurodegeneration in the absence of resolution of inflammation.
Savina Apolloni +11 more
doaj +1 more source
The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases
MedComm, Volume 6, Issue 3, March 2025.Neutrophil extracellular traps (NETs) released by neutrophils in response to pathogens exhibit dual anti‐inflammatory and proinflammatory effects. While effective in pathogen capture and inflammation resolution, imbalanced NET formation can lead to tissue damage and exacerbate inflammatory responses in autoimmune diseases.
Liuting Zeng +4 more
wiley +1 more source
Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies [PDF]
, 2016 Support was kindly provided by the EU COST Action CM1103. DA, KN, and JV kindly acknowledge national project number 172033 and OI1612039 supported by the Ministry of the Republic of Serbia.
Agbaba, Danica +7 more
core +3 more sources
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 11, Issue 1, Page 116-124, March 2025.Abstract Objective Epley maneuver is the most effective treatment for benign paroxysmal positional vertigo (BPPV). Betahistine has been shown to be effective in treating BPPV. This systematic review aims to compare the effectiveness of Epley maneuver with betahistine to Epley maneuver alone in reducing residual dizziness in BPPV.
Renad Alsolamy +2 more
wiley +1 more source
Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]
, 2015 The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana +4 more
core +2 more sources