Results 251 to 260 of about 41,179 (270)

Medicinal chemistry of histamine H3 receptor antagonists

1998
Publisher Summary This chapter discusses medicinal chemistry of histamine H3 receptor antagonists and provides an update on the recent progress being made. Several improved clinical candidates have emerged and are progressing towards human clinical trials.
James G. Phillips, Syed M. Ali
openaire   +2 more sources

Radioligands for the histamine H3 receptor and their use in pharmacology

1998
Publisher Summary This chapter discusses radioligands for the histamine H 3 receptor and their use in pharmacology. Studies performed with H 3 -receptor radioligands have substantially contributed to the current knowledge of the characteristics, distribution, and function of the histamine H 3 -receptor. Tritiated agonists have been successfully used
H. Timmerman, Frank P. Jansen, Rob Leurs
openaire   +2 more sources

Histamine H3 receptors : novel ligands and responses

1992
Abstract The histamine H 3 receptor is an autoreceptor controlling histamine synthesis and release in brain. Imetit S-[2-(imidazol-4-yl)ethyl]isothiourea, a novel, extremely potent and selective H 3 -receptor agonist and its effects in vitro and in vivo are described. H 3 receptors also control enkephalin release in striatum.
Catherine Llorens-Cortes, Charon Robin Ganellin, A. Rouleau, Xavier Ligneau, M. Dam, Trung Tuong, Monique Garbarg, J.M. Arrang, J.-C. Schwartz   +8 more
openaire   +2 more sources

The histamine H3-receptor: A target for developing new drugs

1992
At the beginning of this century histamine was only considered as a mediator of allergic conditions. Indeed, histamine proved to be a very spasmogenic agent of e.g. airway smooth muscle, and intensive research had resulted in the development of several potent “antihistaminergics” (e.g.
H. Timmerman, R. Leurs
openaire   +3 more sources

Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats

European Journal of Pain, 2018
Tanguy Chaumette, E. Chapuy, Esther Berrocoso, Esther Berrocoso, M. Llorca-Torralba, M. Llorca-Torralba, L. Bravo, L. Bravo, J. Micó, J. A. Micó, M. Chalus, Alain Eschalier, D. Ardid, Fabien Marchand, A. Sors   +14 more
semanticscholar   +1 more source

Recent Progress in Histamine H3 Receptor Chemistry

2004
Publisher Summary The third histamine receptor, the H 3 receptor, is a G-protein coupled receptor that functions both as an autoreceptor, controlling the release of histamine from histaminergic neurons, and also as a heteroreceptor, controlling the release of other neurotransmitters such as serotonin and noradrenalin.
Neng-Yang Shih, Robert G. Aslanian
openaire   +2 more sources

New histamine H3 receptor ligands as pharmacological tools

1996
Publisher Summary This chapter discusses the new histamine H 3 receptor ligands as pharmacological tools. In various brain areas, neuronal histamine release and synthesis is regulated presynaptically by histamine H 3 receptors. Recent studies reveal that H 3 receptors not only act as autoreceptors to regulate the release and synthesis of histamine,
Rob Leurs, Henk Timmerman
openaire   +3 more sources

Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain

World Journal of Biological Psychiatry, 2018
A. Tiwari, Danning Zhang, J. Pouget, C. Zai, N. Chowdhury, E. Brandl, L. Qin, Natalie Freeman, J. Lieberman, H. Meltzer, J. Kennedy, D. Müller   +11 more
semanticscholar   +1 more source

[11C]TASP457, a novel PET ligand for histamine H3 receptors in human brain

European Journal of Nuclear Medicine and Molecular Imaging, 2016
Yasuyuki Kimura, C. Seki, Y. Ikoma, M. Ichise, K. Kawamura, K. Takahata, S. Moriguchi, Tomohisa Nagashima, Tatsuya Ishii, S. Kitamura, F. Niwa, H. Endo, M. Yamada, M. Higuchi, Ming-Rong Zhang, T. Suhara   +15 more
semanticscholar   +1 more source

Stress and brain H3-histamine receptors

Inflammation Research, 1995
Carlo Ferretti, P. Portaleone, Marinella Blengio, Piera Ghi   +3 more
openaire   +3 more sources