Journal of Pharmacological Sciences, 2009 Histamine H3 receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes.
Tomohiro Okuda +8 more
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QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression [PDF]
Journal of the Serbian Chemical Society, 2012 A quantitative structure activity relationship (QSAR) model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3) receptors. The molecular structures of the compounds are numerically represented by various
Adimi Maryam +2 more
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Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]
, 2009 Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bamshad +46 more
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Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice
Journal of Pharmacological Sciences, 2008 The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor.
Emiko Yokota +4 more
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Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]
, 2012 Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng +15 more
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Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]
, 2015 The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana +4 more
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Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
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Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
Frontiers in Neuroscience, 2016 With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been
Mohammad eKhanfar +5 more
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Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat [PDF]
, 2004 Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Aarnisalo, Antti A. +4 more
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Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
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