Results 21 to 30 of about 41,179 (270)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken [PDF]

Iranian Journal of Veterinary Medicine, 2017
BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is
Masood GhandForoushan, Morteza Zendehdel, Vahab Babpour   +2 more
doaj   +1 more source

Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens [PDF]

Archives of Razi Institute, 2021
This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control ...
M Mobarhan Fard, B Vazir, M Zendehdel, A Asghari   +3 more
doaj   +1 more source

Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. [PDF]

PLoS ONE, 2014
Histamine H3 receptor therapeutics have been proposed for several diseases such as schizophrenia, attention deficit hyperactivity disorder, Alzheimer's disease and obesity.
David Y Lewis, Sue Champion, David Wyper, Deborah Dewar, Sally Pimlott   +4 more
doaj   +1 more source

The histamine H3 receptor: from gene cloning to H3 receptor drugs [PDF]

Nature Reviews Drug Discovery, 2005
Since the cloning of the histamine H(3) receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well ...
Rob Leurs, Henk Timmerman, Remko A. Bakker, Iwan J. P. de Esch   +3 more
openaire   +3 more sources

Therapeutic Approach of Histamine H3 Receptors in Obesity [PDF]

Recent Patents on CNS Drug Discovery, 2007
Obesity is considered one of the risk factors for metabolic disorders. There is increasing evidence that obesity is under control of several cytokines and hormone in the brain. Brain histamine and H3 receptors are important factors for regulating obesity.
Takayuki, Masaki, Hironobu, Yoshimatsu
openaire   +3 more sources

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

bioRxiv, 2019
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death.
D. Moreno-Delgado, M. Puigdellívol, E. Moreno, Mar Rodríguez-Ruiz, J. Botta, P. Gasperini, A. Chiarlone, L. Howell, M. Scarselli, V. Casadó, Antonio Cortés, S. Ferré, M. Guzmán, C. Lluis, J. Alberch, E. Canela, S. Ginés, P. McCormick   +17 more
semanticscholar   +1 more source

Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET

British Journal of Pharmacology, 2020
BF2.649 (pitolisant, Wakix®) is a novel histamine H3 receptor inverse agonist/antagonist recently approved for the treatment of narcolepsy disorder. The objective of the study was to investigate in vivo occupancy of H3 receptors by BF2.649 using PET ...
P. Rusjan, P. Sabioni, P. Di Ciano, E. Mansouri, I. Boileau, A. Laveillé, M. Capet, T. Duvauchelle, J. Schwartz, P. Robert, B. Le Foll   +10 more
semanticscholar   +1 more source

QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression [PDF]

Journal of the Serbian Chemical Society, 2012
A quantitative structure activity relationship (QSAR) model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3) receptors. The molecular structures of the compounds are numerically represented by various
Adimi Maryam, Salimi Mahmoud, Nekoei Mehdi   +2 more
doaj   +1 more source