Results 61 to 70 of about 41,179 (270)
European Journal of Organic Chemistry, EarlyView.In an environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest, imidazo[1,2‐a]pyridine, imidazo[1,2‐a]pyrazine and imidazo[1,2‐b]pyridazine core structures are obtained by a multicomponent Groebke–Blackburn–Bienaymé reaction using bio‐based recyclable solvents.
Abdelkarim El Qami +5 more
wiley +1 more source
Angewandte Chemie, 2019 Spatiotemporal control over biochemical signaling processes involving G protein‐coupled receptors (GPCRs) is highly desired for dissecting their complex intracellular signaling.
Niels J Hauwert +8 more
semanticscholar +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar +4 more
wiley +1 more source
Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2017 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
core +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Early Origins of Asthma and Allergies: Clues From Studies in China
Clinical &Experimental Allergy, EarlyView.The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang +5 more
wiley +1 more source
The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats
Frontiers in Neuroscience, 2018 The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted.
Nermin Eissa +5 more
semanticscholar +1 more source
The Effects of Histamine H3 Receptors on Contractile Responses on Rat Gastric Fundus [PDF]
, 2006 The aim of this study is to determine the effects of histamine receptors on the gastrointestinal system smooth muscle contractions and the role of histamine H3 receptors on these effects.
Aşkın Hekimoğlu, Ramazan Çiçek
core