Results 71 to 80 of about 41,179 (270)
Pharmacology Research & Perspectives, 2022 The prolonged exposure to obesogenic diets disrupts the mesocortical dopaminergic input to the prefrontal cortex (PFC). This leads to suboptimal dopamine levels in this brain region, which affects cognition and control of food intake.
Ike C. dela Peña +2 more
doaj +1 more source
Histamine H3 Receptor Antagonists Go to Clinics
Biological and Pharmaceutical Bulletin, 2008 Within the recent years novel lead optimisations for histamine H(3) receptor antagonists made their way from bench to bedside. Structure-activity relationships, cross-affinities and side effects as well as pharmacokinetic profiling will be discussed on selected promising compound series.
Kerstin Sander, Holger Stark, Tim Kottke
openaire +4 more sources
Epilepsia, EarlyView.Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher +1 more
wiley +1 more source
Scientific Reports, 2017 Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H3 receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unclear
J. Guilloux +11 more
semanticscholar +1 more source
Superconductivity of Pure H3S Synthesis from Elemental Sulfur and Hydrogen [PDF]
J. Phys. Soc. Jpn. 88, 123701 (2019), 2019 Superconductive H3S synthesized from H2S is very poorly crystallized, and has excess sulfur as impurity (3H2S -> 2H3S + S). The phase transition process undergoes in sulfur excess condition, which might cause hydrogen deficiency. The influence of hydrogen deficiency is not clear.
arxiv +1 more source
Therapeutic potential of histamine H3 receptor agonists and antagonists
Trends in Pharmacological Sciences, 1998 The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timmerman describe the available H3 ...
R. LEURS +3 more
openaire +6 more sources
Narcolepsy and rapid eye movement sleep
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini +4 more
wiley +1 more source
Histamine H3 Receptors Expressed in Ventral Horns Modulate Spinal Motor Output [PDF]
, 2020 Motoneuron activity is modulated by histamine receptors. While H1 and H2 receptors have been widely explored, H3 histamine receptors (H3Rs) have not been sufficiently characterized.
Coslovich, T. +4 more
core +1 more source
Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria. [PDF]
PLoS ONE, 2009 BACKGROUND:Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria.
Walid Beghdadi +9 more
doaj +1 more source
Neurogastroenterology &Motility, EarlyView.In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source