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Classical Hodgkin lymphoma associated with immune deficiency and dysregulation exhibits a prognosis similar to sporadic cases but with distinct predictive markers. [PDF]

Ann Hematol
Mukae J, Akiyama H, Tanaka K, Yoshifuji K, Nogami A, Umezawa N, Umezawa Y, Yamamoto K, Nagao T, Yasuda S, Kanegane H, Takagi M, Mori T, Yamamoto M.   +13 more
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Interleukin 2 receptors

Leukemia Research, 1990
Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the alpha chain (or p55 or Tac) and the beta chain (or p70 or p75). The association of both chains constitutes high affinity IL2-R complexes (Kd congruent to 10-100 pM), whereas the alpha-chain or the beta chain alone bind IL-2 with low (Kd congruent to 5-50 nM) and intermediate ...
M, Allouche, Y, Sahraoui, Y, Augery-Bourget, M, Perrakis, C, Jasmin, V, Georgoulias   +5 more
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The Human Interleukin-2 Receptor

Annual Review of Immunology, 1986
In 1976, Morgan et al first reported the presence of a T-cell growth­ promoting activity in the supernatants of activated T-cell cultures; they denoted this T-cell growth factor (TCGF) (1). In subsequent years, TCGF was characterized as a distinct biochemical entity and found to be a 15,500dalton glycoprotein (2).
W C, Greene, W J, Leonard
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The human interleukin-2 receptor

Journal of Cell Science, 1985
ABSTRACT Complementary DNAs corresponding to the human receptor for interleukin-2 (IL-2) have been molecularly cloned, sequenced, and expressed in both COS-1 and L cells. The human genome appears to contain a single structural gene for this receptor located on the short arm of chromosome 10 (band 14-15).
W C, Greene, J M, Depper, M, Krönke, W J, Leonard   +3 more
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Regulation of Interleukin 2 Receptor Expression by Interleukin 2

Scandinavian Journal of Immunology, 1986
The regulatory influence of Interleukin 2 (IL‐2) on the expression of IL‐2 receptors (IL.‐2R) was studied using long‐term cultured T‐cell lines and recombinant IL‐2 (r‐IL‐2). Three T‐cell lines with different growth requirements were used as model systems: insulin‐specific BK‐BI‐1.2 cells express IL‐2R transiently after antigenic restimulation ...
A B, Reske-Kunz, D, von Steldern, E, Rüde, T, Diamantstein   +3 more
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Interleukin 2/interleukin 2 receptor system in type 1 diabetes

Diabetes Research and Clinical Practice, 1989
There is increasing evidence that cellular immune abnormalities are involved in the pathogenesis of type 1 diabetes mellitus. The non-obese diabetic (NOD) mouse, a model of human type 1 diabetes, develops mononuclear cell infiltration of its pancreatic islets (insulitis), leading to /3 cell destruction and overt diabetes [l]. In recent studies, most of
N, Hatamori, K, Yokono, M, Nagata, K, Doi, S, Baba   +4 more
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Interleukin-2 Receptors

1985
Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Thomas A. Waldmann, Warren J. Leonard, Joel M. Depper, Martin Kronke, Carolyn K. Goldman, Kathleen Bongiovanni, Warner C. Greene   +6 more
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Interleukin-2 receptors in infectious mononucleosis

Immunology Letters, 1989
The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a ...
C, Schmidt, K, Burman, D J, Moss, J, Ryan, S R, Burrows, I S, Misko   +5 more
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