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Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis [PDF]
Arthritis & Rheumatism, 1990 Cell-mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin-2 receptors (IL-2R), IL-1 alpha, and IL-2 were correlated with creatine kinase (CK) levels ...
R. Wolf, B. Baethge
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Leukemia Research, 1990
Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the alpha chain (or p55 or Tac) and the beta chain (or p70 or p75). The association of both chains constitutes high affinity IL2-R complexes (Kd congruent to 10-100 pM), whereas the alpha-chain or the beta chain alone bind IL-2 with low (Kd congruent to 5-50 nM) and intermediate ...
Maria Perrakis +7 more
openaire +2 more sources
Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the alpha chain (or p55 or Tac) and the beta chain (or p70 or p75). The association of both chains constitutes high affinity IL2-R complexes (Kd congruent to 10-100 pM), whereas the alpha-chain or the beta chain alone bind IL-2 with low (Kd congruent to 5-50 nM) and intermediate ...
Maria Perrakis +7 more
openaire +2 more sources
, 1993
Objective. To assess whether circulating concentrations of soluble tumor necrosis factor receptors (sTNFR; p55 and p75), soluble interleukin-2 receptors (sIL-2R), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) reflect clinical response and ...
P. Barrera +9 more
semanticscholar +1 more source
Objective. To assess whether circulating concentrations of soluble tumor necrosis factor receptors (sTNFR; p55 and p75), soluble interleukin-2 receptors (sIL-2R), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) reflect clinical response and ...
P. Barrera +9 more
semanticscholar +1 more source
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.
Science, 1993The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also ...
M. Kondo +6 more
semanticscholar +1 more source
The human interleukin-2 receptor
Journal of Cell Science, 1985ABSTRACT Complementary DNAs corresponding to the human receptor for interleukin-2 (IL-2) have been molecularly cloned, sequenced, and expressed in both COS-1 and L cells. The human genome appears to contain a single structural gene for this receptor located on the short arm of chromosome 10 (band 14-15).
Joel M. Depper +3 more
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The Human Interleukin-2 Receptor
Annual Review of Immunology, 1986In 1976, Morgan et al first reported the presence of a T-cell growth promoting activity in the supernatants of activated T-cell cultures; they denoted this T-cell growth factor (TCGF) (1). In subsequent years, TCGF was characterized as a distinct biochemical entity and found to be a 15,500dalton glycoprotein (2).
Warner C. Greene, Warren J. Leonard
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Regulation of Interleukin 2 Receptor Expression by Interleukin 2
Scandinavian Journal of Immunology, 1986The regulatory influence of Interleukin 2 (IL‐2) on the expression of IL‐2 receptors (IL.‐2R) was studied using long‐term cultured T‐cell lines and recombinant IL‐2 (r‐IL‐2). Three T‐cell lines with different growth requirements were used as model systems: insulin‐specific BK‐BI‐1.2 cells express IL‐2R transiently after antigenic restimulation ...
T. Diamantstein +3 more
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The Interleukin‐2 Receptor: A Target for Immunotherapy
Annals of the New York Academy of Sciences, 1992Immune intervention began almost two centuries ago when Jenner introduced vaccination with cowpox as a means of protecting against smallpox. This form of immune intervention plays a dominant role in the prevention of human disease. Furthermore, immunological approaches including radioimmunoassays, enzyme-linked immunoassays, microfluorometry, and ...
James C. Reynolds +21 more
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