Results 241 to 250 of about 1,144,647 (289)
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Pathology, 1991
Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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The released interleukin 2 receptor binds interleukin 2 efficiently.
The Journal of Immunology, 1986Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
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INTERLEUKIN 2 RECEPTOR-DIRECTED IMMUNOSUPPRESSIVE THERAPY
1987An ideal antirejection therapy should, of course, be effective in controlling rejection as well as selectively target only those T-cells that are committed to participate in rejection of the donor graft. Conventional immunosuppressive drugs exact unwanted side effects upon non-lymphoid tissues. The introduction of monoclonal antibodies as pharmacologic
T. B. Strom +9 more
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Acta Endocrinologica, 1989
Abstract. The present study was undertaken to examine the cellular control arm of the immune response with regard to T lymphocyte proliferation in euthyroid Graves' ophthalmopathy. Twenty patients with euthyroid Graves' ophthalmopathy (7 on antithyroid drugs and 13 on no treatment) and 18 healthy controls were studied in an infection-free period ...
Chow, CC +3 more
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Abstract. The present study was undertaken to examine the cellular control arm of the immune response with regard to T lymphocyte proliferation in euthyroid Graves' ophthalmopathy. Twenty patients with euthyroid Graves' ophthalmopathy (7 on antithyroid drugs and 13 on no treatment) and 18 healthy controls were studied in an infection-free period ...
Chow, CC +3 more
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Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages
Cellular Immunology, 1990Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors ...
M, Belosevic, C A, Nacy
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Interleukin-2 receptor expression and interleukin-2 production in bullous pemphigoid
Archives of Dermatological Research, 1990Expression of interleukin-2 (IL2) receptors was studied on peripheral blood lymphocytes (PBLs) in 25 patients with bullous pemphigoid. Analysis was carried out by flow cytometry. Without immunosuppressive therapy expression of IL2 receptors only on T cells (CD5) was significantly increased as shown by double staining (11.9% +/- 7.8% vs 2.1% +/- 1% in ...
J, Schaller +3 more
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Biology of the Interleukin-2 Receptor
1998Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the interactions among vast numbers of lymphocytes, comprising a number of functionally distinct ...
B H, Nelson, D M, Willerford
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Human interleukin 2 receptor (Tac antigen)
1987Publisher Summary This chapter discusses the biochemical and molecular techniques that have permitted characterization of the human IL-2 receptor (Tac antigen) at the gene, mRNA, and protein levels. Unlike receptors for antigen, IL-2 receptors (Tac antigens) are not present on the surface of resting T cells, but like IL-2, they are induced by the ...
W C, Greene, W J, Leonard
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Biochemical and Biophysical Research Communications, 1993
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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Serum Interleukin-2 and Soluble Interleukin-2 Receptor in Gestrational Trophoblastic Diseases
Journal of the Society for Gynecologic Investigation, 1996To investigate serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2) levels in gestational trophoblastic diseases (GTD).Sixty-six patients with GTDs and 23 first-trimester healthy pregnant women (controls) participated in this study.
M, Shaarawy, N A, Darwish, O, Abdel-Aziz
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