Results 281 to 290 of about 90,104 (295)
Some of the next articles are maybe not open access.
Leptin and leptin receptor-related monogenic obesity
Biochimie, 2012The studies based on candidate genes and encoded proteins known to cause severe obesity in rodents, have shown that these genes also contribute to human early-onset obesity especially for those involved in the leptin pathway: the leptin (LEP) and leptin receptor (LEPR) genes.
Karine Clément, Béatrice Dubern
openaire +3 more sources
Role of leptin and leptin receptors in hematological malignancies
Leukemia & Lymphoma, 2015Leptin is an adipose-derived cytokine that has an important role in bodyweight homeostasis and energy balance. There are a number of studies which have suggested that leptin and its receptors dysregulation play a critical role in the development of malignancies including hematological malignancies, mainly via activation of the JAK/STAT pathway which ...
Ramzi M. Mohammad, Shahab Uddin
openaire +2 more sources
Localization of Leptin Binding Domain in the Leptin Receptor
Molecular Pharmacology, 1998The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid sequence of the extracellular region of the cloned leptin receptor differs from that of many other cytokine receptors in that it contains two homologous segments representing potential ligand ...
R.-R. C. Huang +8 more
openaire +3 more sources
Localization of leptin and leptin receptor in the bovine adenohypophysis
Domestic Animal Endocrinology, 2008The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of ...
Kouichi Watanabe +8 more
openaire +3 more sources
Immunoassays for Leptin and Leptin Receptors
2006Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
openaire +2 more sources
Expression of leptin and leptin receptors in gestational trophoblastic diseases
Gynecologic Oncology, 2004To investigate the expression profile of leptin and leptin receptors in gestational trophoblastic diseases (GTDs).Using immunohistochemical staining on archival paraffin-embedded tissue sections, we studied the expression of leptin and leptin receptor in hydatidiform moles, with gestational age-matched normal first-trimester placenta used as control. A
Li, RHW, Yu, MMY, Wong, YF, Cheung, ANY
openaire +5 more sources
Human mast cells express leptin and leptin receptors
Histochemistry and Cell Biology, 2009Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells.
Taildeman, Jasmien +10 more
openaire +5 more sources
Research in Veterinary Science, 2013
Leptin is a Ob gene product secreted mainly by adipose tissue. Several reports showed leptin production by other tissue including the ovary. The action of leptin is mediated upon binding to its receptor widely expressed in reproductive tissues in different species.
ALBRIZIO, MARIA +5 more
openaire +3 more sources
Leptin is a Ob gene product secreted mainly by adipose tissue. Several reports showed leptin production by other tissue including the ovary. The action of leptin is mediated upon binding to its receptor widely expressed in reproductive tissues in different species.
ALBRIZIO, MARIA +5 more
openaire +3 more sources
The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
Trends in Pharmacological Sciences, 1999Support for our work comes mostly from the Centre National de la Recherche Scientifique, the Institut National de la Sante et de la Recherche Medicale, the University of Paris VII, the Ministry for Research and Technology. We are also grateful for help from the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Medicale Francaise and ...
Arthur Donny Strosberg, Tarik Issad
openaire +3 more sources
Serum leptin levels, skin leptin and leptin receptor expression in psoriasis
British Journal of Dermatology, 2008Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
Mehmet Onur Elbasi +5 more
openaire +3 more sources