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Homology Modeling of Human Leptin/ Leptin Receptor Complex
Biochemical and Biophysical Research Communications, 2000Leptin receptor mediates the weight regulatory signal carried by the adipocyte-secreted peptide hormone, leptin. It is important to understand the atomic interactions between leptin and the receptor for the therapeutic applications. However, the structure of leptin receptor has not yet been determined. Leptin shows structural similarity to G-CSF, while
Hisato Jingami+3 more
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Measurement of Circulating Leptin and Soluble Leptin Receptors
2014Shortly following the discovery of leptin methods were developed to measure this novel adipokine in the circulation. The finding of multiple splice variants of the leptin receptor gene, including an mRNA for a soluble leptin receptor, suggested the presence of a circulating leptin binding protein. It was subsequently demonstrated that leptin associated
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