Results 311 to 320 of about 444,848 (367)

Modulation of Epidermal Growth Factor Receptors on 3T3 Cells by Platelet-Derived Growth Factor

Science, 1980
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors.
CF Fox, M Wrann, Russell Ross
openaire   +4 more sources

Mechanism of action and in vivo role of platelet-derived growth factor.

Physiological Reviews, 1999
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and ...
C. Heldin, B. Westermark
semanticscholar   +1 more source

Expression of platelet‐derived growth factor‐AA and platelet‐derived growth factor‐α receptor in ameloblastomas

Journal of Oral Pathology & Medicine, 2008
Background:  Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method:  Twenty‐nine specimens of ...
Nikolaus Wick, Peter R. Mazal, Irene Sulzbacher, Bettina Pichlhofer   +3 more
openaire   +3 more sources

Signal Transduction by the Platelet-Derived Growth Factor Receptor [PDF]

Science, 1989
When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a remarkably diverse group of biochemical responses, including changes in ion fluxes, activation of several kinases, alterations in cell shape, increased transcription of a number of genes, and stimulation of enzymes that ...
openaire   +2 more sources

Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571.

Clinical Cancer Research, 2019
PURPOSE Osteosarcoma is an aggressive primary bone cancer characterized by expression of platelet-derived growth factor (PDGF) and its cognate receptor.
E. McGary, Kristy Weber, L. Mills, M. Doucet, Valerie Lewis, D. Lev, I. Fidler, M. Bar‐eli   +7 more
semanticscholar   +1 more source

Commentary Signal transduction by the receptors for platelet-derived growth factor

Journal of Cell Science, 1990
ABSTRACT Platelet-derived growth factor CPDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF
Westermark B, C H Heldin
openaire   +3 more sources

Expression of platelet-derived growth factor B-chain and platelet-derived growth factor β-receptor in fibroblasts of scleroderma

Journal of Dermatological Science, 1998
Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong, Ping Tu, Shengqing Ma, Zheng Xueyi   +3 more
openaire   +3 more sources

Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro.

Endocrinology, 1992
Immunohistochemical observations indicate that human myometrial smooth muscle cells express epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-AB and contain EGF and PDGF-beta receptors with no variation in intensity with phases of ...
Michael J. Rossi, N. Chegini, Byron J. Masterson   +2 more
semanticscholar   +1 more source

Platelet derived growth factor and its receptor in intracerebral hemorrhage

Journal of Zhejiang University (Medical Sciences), 2022
Intracerebral hemorrhage (ICH) is a common and highly disabling or fatal neurological disorder in adults. Recent studies have suggested that the platelet derived growth factor (PDGF) signaling pathway plays an important role in the development of ICH. PDGF is involved in vascular remodeling and can be used as a biomarker of cerebral amyloid angiopathy ...
Baojie, Mao, Ming, Wang, Shu, Wan
openaire   +2 more sources

The platelet-derived growth factor receptor as a therapeutic target

Current Oncology Reports, 2007
Several small molecule tyrosine kinase inhibitors that block the epidermal growth factor receptor and vascular endothelial growth factor receptor function are among the many recently developed targeted anticancer therapeutic agents. Increasing evidence indicates that inhibition of other tumor stromal targets could provide additional and possibly ...
openaire   +3 more sources