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[8] methods for studying the platelet-derived growth factor receptor

1985
Publisher Summary This chapter discusses the factors that affect [ 125 I] platelet-derived growth factory (PDGF) binding, or the evaluation of binding, on the evidence that the observed binding is to a functional receptor and on the development of a radioreceptor assay for PDGF. It is a basic 30,000-dalton protein.
Daniel F. Bowen-Pope, Russell Ross
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Structural and functional aspects of the receptors for platelet-derived growth factor

Progress in Growth Factor Research, 1989
Platelet-derived growth factor (PDGF) is a 30 kDa dimer of disulfide-bonded A and B chains. Three isoforms of PDGF have been isolated (PDGF-AA, PDGF-AB and PDGF-BB). These bind with different affinities and specificities to two structurally related cell surface receptors, viz. the alpha-receptor and the beta-receptor.
Lena Claesson-Welsh, Carl-Henrik Heldin, Bengt Westermark   +2 more
openaire   +3 more sources

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

Nature, 1994
Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly understood. Platelet-derived growth factor (PDGF) acts both as a mitogen and a chemoattractant. Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a ...
Sue Goo Rhee, Vikas Kundra, Bruce R. Zetter, Jaime Escobedo, Ha Kun Kim, Lewis T. Williams, Andrius Kazlauskas   +6 more
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Caveolin Is an Inhibitor of Platelet-Derived Growth Factor Receptor Signaling

Experimental Cell Research, 1999
Caveolin is a major structural component of caveolae and has been implicated in the regulation of the function of several caveolae-associated signaling molecules. Platelet-derived growth factor (PDGF) receptors and caveolin were colocalized in the same subcellular fraction after sucrose density gradient fractionation of fibroblasts.
Yoshihiro Ishikawa, Roy A. Jensen, Manabu Yamamoto, Yoshiyuki Toya   +3 more
openaire   +3 more sources

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice

Current Opinion in Nephrology and Hypertension, 2004
The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge, Mattias Bjarnegård, Holger Gerhardt, Per Lindblom, Christer Betsholtz, Per Lindahl   +5 more
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Receptors for platelet-derived growth factor on microvascular endothelial cells

1992
Endothelial cells are widely thought to be unresponsive to platelet-derived growth factor (PDGF) and devoid of PDGF receptors. However, in examining the growth factor responses of microvascular endothelial cells isolated from human omental adipose tissue, we detected PDGF-induced tyrosine phosphorylation of an 180-kD glycoprotein, subsequently ...
Frackelton Ar, Paul Calabresi, Insoon Kim, Julie Beitz   +3 more
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Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis.

Arthritis & Rheumatism, 1990
The expression of B-type receptors for platelet-derived growth factor (PDGF) was investigated in skin biopsy samples from patients with systemic sclerosis (SSc), by immunohistochemical staining using monoclonal antibodies specific for the receptor ...
L. Klareskog, R. Gustafsson, A. Scheynius, R. Hällgren   +3 more
semanticscholar   +1 more source

Receptors | Platelet-Derived Growth Factor Receptor Family

Encyclopedia of Biological Chemistry III, 2021
M. Kovalenko, A. Kazlauskas, Vivian Kitainda   +2 more
semanticscholar   +1 more source

Platelet-Derived Growth Factor B Type Receptor

1990
Platelet-derived growth factor (PDGF) is a major mitogen in serum for connective tissue cells (for reviews, see Heldin et al., 1985; Ross et al., 1986). The in vivo function of PDGF is not known. However, the fact that PDGF is released from platelets in conjunction with the blood coagulation and stimulates not only proliferation, but also chemotaxis ...
Lars Rönnstrand, Carl-Henrik Heldin
openaire   +2 more sources

Interaction of receptors for insulin-like growth factor I, platelet-derived growth factor, and fibroblast growth factor in rat aortic cells.

Endocrinology, 1987
Serum contains various growth factors which regulate the proliferation of cells. We investigated the growth of cultured arterial smooth muscle cells under the influence of insulin-like growth factor I (IGF I), fibroblast growth factor (FGF), and platelet-
B. Pfeifle, H. Boeder, H. Ditschuneit
semanticscholar   +1 more source