Results 151 to 160 of about 6,767 (186)

Eltrombopag: A Novel Oral Thrombopoietin Receptor Agonist

Annals of Pharmacotherapy, 2010
To review the pharmacology and pharmacokinetics and evaluate the safety and efficacy of eltrombopag for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and thrombocytopenia associated with hepatitis C virus (HCV) cirrhosis.A Cochrane Controlled Trial Register, clinicaltrials.gov, EMBASE, and MEDLINE search was performed ...
Shelby L, Corman, Rima A, Mohammad
openaire   +2 more sources

Phenotypic Screening for Inhibitors of a Mutant Thrombopoietin Receptor

2018
An inhibitor for the thrombopoietin receptor (TpoR) would be more specific for the treatment of myeloproliferative neoplasms (MPNs) due to constitutively active mutant TpoR compared to the current treatment approach of inhibiting Janus kinase 2 (JAK2).
Anna, Ngo, Ann, Koay, Christian, Pecquet, Carmen C, Diaconu, David A, Jenkins, Andrew K, Shiau, Stefan N, Constantinescu, Meng Ling, Choong   +7 more
openaire   +2 more sources

Thrombopoietin Receptor Agonist Use for Immune Thrombocytopaenia

Hämostaseologie, 2019
AbstractManagement of patients with corticosteroid-refractory immune thrombocytopaenia (ITP) possesses a significant challenge to practitioners. Until recently, options included splenectomy and immunosuppression. With improved knowledge of both thrombopoiesis and the pathophysiology of ITP, novel drug development with thrombopoietin-receptor agonists ...
openaire   +2 more sources

Update on the Use of Thrombopoietin-Receptor Agonists in Pediatrics

Hämostaseologie
AbstractThis review summarizes the rationale and current data on the use of thrombopoietin receptor agonists (TPO-RAs) for treating severe thrombocytopenia in infants, children, and adolescents. It focuses on substances that have been approved by the U.S.
Jennifer, Gebetsberger, Werner, Streif, Christof, Dame   +2 more
openaire   +2 more sources

The thrombopoietin receptor: revisiting the master regulator of platelet production

Platelets, 2021
Ian Hitchcock, Veena Sangkhae, Julie Tucker   +2 more
exaly  

Structural studies of the thrombopoietin–thrombopoietin receptor signalling complex

Acta Crystallographica Section A Foundations and Advances, 2023
K. T. G Sarson-Lawrence, J. M. Hardy, J. Iaria, T. Saiyed, A. P. Leis, J. J. Babon, N. J. Kershaw   +6 more
openaire   +1 more source

Thrombopoietin receptor

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source

Emerging data on thrombopoietin receptor agonists for management of chemotherapy-induced thrombocytopenia

Expert Review of Hematology, 2023
Hanny Al-Samkari, Andrew Song
exaly  

Thrombopoietin and thrombopoietin receptor agonists

2016
openaire   +1 more source

Optimal use of thrombopoietin receptor agonists in immune thrombocytopenia

Therapeutic Advances in Hematology, 2019
Hanny Al-Samkari, David Kuter
exaly