Results 151 to 160 of about 6,730 (183)

Eltrombopag: A Novel Oral Thrombopoietin Receptor Agonist

Annals of Pharmacotherapy, 2010
To review the pharmacology and pharmacokinetics and evaluate the safety and efficacy of eltrombopag for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and thrombocytopenia associated with hepatitis C virus (HCV) cirrhosis.A Cochrane Controlled Trial Register, clinicaltrials.gov, EMBASE, and MEDLINE search was performed ...
Shelby L, Corman, Rima A, Mohammad
openaire   +2 more sources

Phenotypic Screening for Inhibitors of a Mutant Thrombopoietin Receptor

2018
An inhibitor for the thrombopoietin receptor (TpoR) would be more specific for the treatment of myeloproliferative neoplasms (MPNs) due to constitutively active mutant TpoR compared to the current treatment approach of inhibiting Janus kinase 2 (JAK2).
Anna, Ngo, Ann, Koay, Christian, Pecquet, Carmen C, Diaconu, David A, Jenkins, Andrew K, Shiau, Stefan N, Constantinescu, Meng Ling, Choong   +7 more
openaire   +2 more sources

New thrombopoietin receptor agonists for platelet disorders

Drugs of Today, 2012
Since thrombopoietin (TPO) was cloned in 1994, TPO receptor (TPO-R) agonists have been developed which have shown significant clinical activity in various conditions characterized by thrombocytopenia. First-generation TPO-R agonists were recombinant forms of human TPO.
S, Homeida, C, Ebdon, P, Batty, B, Jackson, S, Kolade, C, Bateman, Y Y, Peng, R, Stasi   +7 more
openaire   +2 more sources

Pyrimidine benzamide-based thrombopoietin receptor agonists

Bioorganic & Medicinal Chemistry Letters, 2007
A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by ...
Lawrence A, Reiter, Chakrapani, Subramanyam, Emilio J, Mangual, Christopher S, Jones, Marc I, Smeets, William H, Brissette, Sandra P, McCurdy, Paul D, Lira, Robert G, Linde, Qifang, Li, Fangning, Zhang, Amy S, Antipas, Laura C, Blumberg, Jonathan L, Doty, James P, Driscoll, Michael J, Munchhof, Sharon L, Ripp, Andrei, Shavnya, Richard M, Shepard, Diana, Sperger, Lisa M, Thomasco, Kristen A, Trevena, Lilli A, Wolf-Gouveia, Liling, Zhang   +23 more
openaire   +2 more sources

Thrombopoietin Receptor Agonist Use for Immune Thrombocytopaenia

Hämostaseologie, 2019
AbstractManagement of patients with corticosteroid-refractory immune thrombocytopaenia (ITP) possesses a significant challenge to practitioners. Until recently, options included splenectomy and immunosuppression. With improved knowledge of both thrombopoiesis and the pathophysiology of ITP, novel drug development with thrombopoietin-receptor agonists ...
openaire   +2 more sources

Update on the Use of Thrombopoietin-Receptor Agonists in Pediatrics

Hämostaseologie
AbstractThis review summarizes the rationale and current data on the use of thrombopoietin receptor agonists (TPO-RAs) for treating severe thrombocytopenia in infants, children, and adolescents. It focuses on substances that have been approved by the U.S.
Jennifer, Gebetsberger, Werner, Streif, Christof, Dame   +2 more
openaire   +2 more sources

Structural studies of the thrombopoietin–thrombopoietin receptor signalling complex

Acta Crystallographica Section A Foundations and Advances, 2023
K. T. G Sarson-Lawrence, J. M. Hardy, J. Iaria, T. Saiyed, A. P. Leis, J. J. Babon, N. J. Kershaw   +6 more
openaire   +1 more source

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Cell, 2023
Naotaka Tsutsumi, K Christopher Garcia
exaly  

The thrombopoietin receptor: revisiting the master regulator of platelet production

Platelets, 2021
Ian S Hitchcock, Maximillian Hafer, Veena Sangkhae   +2 more
exaly  

The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag

Blood Reviews, 2022
David J Kuter
exaly