Results 311 to 320 of about 491,094 (347)

Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors as Anti-Angiogenic Agents in Cancer Therapy

Recent Patents on Anti-Cancer Drug Discovery, 2007
New blood vessel formation (angiogenesis) is fundamental to the process of tumor growth, invasion, and metastatic dissemination. The vascular endothelial growth factor (VEGF) family of ligands and receptors are well established as key regulators of these processes.
Anand, Veeravagu, Andrew R, Hsu, Weibo, Cai, Lewis C, Hou, Victor C K, Tse, Xiaoyuan, Chen   +5 more
openaire   +2 more sources

Comparative Analysis of Vascular Endothelial Growth Factor Receptors on Retinal and Aortic Vascular Endothelial Cells

Diabetes, 1995
Ischemic eye disease often results in ocular neovascularization, presumably due to the elaboration of growth factors. Diabetic retinopathy is a classic example in which dramatic retinal neovascularization arises after ischemic retinal damage. The characterization of vascular endothelial growth factor (VEGF) as an angiogenic molecule whose expression is
H, Thieme, L P, Aiello, H, Takagi, N, Ferrara, G L, King   +4 more
openaire   +2 more sources

The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland

Growth Factors, 2010
H. Sagsoz, M. Ketani
semanticscholar   +1 more source

Inhibitors of Vascular Endothelial Growth Factor Receptor

2017
Angiogenesis-targeting agents, predominantly inhibitors of vascular endothelial growth factor and its receptors, have become a mainstay in oncology practice over the last decade. The approved drugs, which include two antibodies and seven small molecule inhibitors, represent strong validation for the field of anti-angiogenesis in the treatment of cancer.
openaire   +1 more source

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.

Journal of Clinical Oncology, 2005
D. Hicklin, L. Ellis
semanticscholar   +1 more source

Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis

2001
Abstract The development of the vascular and hematopoietic systems of the vertebrate embryo occurs during early ontogeny and requires a variety of control mechanisms: those that specify mesodermal cells to form the lineage constituents, and those that control their proliferation and their coalescence to form a primitive vascular network.
Kari Alitalo, Yuji Gunji, Riitta Alitalo,, Anne Eichmann   +3 more
openaire   +1 more source

A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis.

Cancer research, 2002
Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We
T P, Quinn, S J, Soifer, K, Ramer, L T, Williams, M C, Nakamura   +4 more
openaire   +1 more source

Cancer treatment and survivorship statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Kimberly D Miller, Leticia M Nogueira, Angela B Mariotto   +2 more
exaly  

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer.

Human Pathology, 1995
L. Brown, B. Berse, R. Jackman, K. Tognazzi, Anthony J. Guidi, H. Dvorak, D. Senger, J. Connolly, S. Schnitt   +8 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly