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Vasopressin V2 receptors, ENaC, and sodium reabsorption: a risk factor for hypertension?

AJP - Renal Physiology, 2010
Excessive sodium reabsorption by the kidney has long been known to participate in the pathogenesis of some forms of hypertension. In the kidney, the final control of NaCl reabsorption takes place in the distal nephron through the amiloride-sensitive ...
L. Bankir, D. Bichet, N. Bouby
semanticscholar   +1 more source

Vascular vasopressin receptors

General Pharmacology: The Vascular System, 1988
1. Vascular vasopressin receptors are understood because of the specific application of each major technical advance in pharmacology; this review shows that isolated organs, whole animal preparations, hormone synthesis, radioligand binding, and human studies have all played their part. 2. Even so, neither vascular vasopressin receptor heterogeneity nor
openaire   +3 more sources

Human platelet vasopressin receptors

Life Sciences, 1982
Specific saturable binding of 125I-arginine-vasopressin to human platelets is described. For ten normal volunteers the mean (+/- S.D.) KD is 5.6 nM (+/- 2.1) and the mean (+/- S.D.) Bmax is 115 fmoles/mg protein (+/- 30). Association studies indicate that equilibrium is reached after 90 minutes on ice.
Robert M. Post   +3 more
openaire   +3 more sources

Vasopressin Receptor Antagonists

Current Hypertension Reports, 2015
Arginine vasopressin (AVP) is the principal hormone involved in regulating the tonicity of body fluids. Less appreciated is the role that AVP plays in a variety of other physiologic functions including glucose metabolism, cardiovascular homeostasis, bone metabolism, and cognitive behavior.
openaire   +2 more sources

Vasopressin and oxytocin receptors

Baillière's Clinical Endocrinology and Metabolism, 1996
The oxytocin and the vasopressin V1a, V1b and V2 receptors have recently been cloned and shown to form a sub-family within the large superfamily of G-protein-linked receptors. Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.
openaire   +3 more sources

Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice.

Journal of Neurotrauma, 2008
Brain edema is still one of the most deleterious sequels of traumatic brain injury (TBI), and its pathophysiology is not sufficiently understood. The goal of the current study was to investigate the role of arginine vasopressin (AVP), also known as ...
Raimund Trabold   +3 more
semanticscholar   +1 more source

Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.

AJP - Renal Physiology, 2008
The neuropeptide hormone arginine-vasopressin (AVP) is well known to exert its antidiuretic effect via the vasopressin V2 receptor (V2R), whereas the role of the vasopressin V1a receptor (V1aR) in the kidney remains to be clarified.
T. Aoyagi   +16 more
semanticscholar   +1 more source

Vasopressin Receptors in Voiding Dysfunction

2011
Arginine vasopressin (AVP), also known as vasopressin or anti-diuretic hormone, is a neuropeptide produced in the hypothalamus. It is primarily responsible for osmoregulation and thus maintains body fluid homeostasis. It is also a potent vasoconstrictor, may have a role in higher cognitive functions and affects metabolism.
Sailaja Pisipati, Hashim Hashim
openaire   +3 more sources

Solubilization of Vasopressin Receptors

1991
Publisher Summary This chapter provides an overview of the solubilization of vasopressin receptors. Vasopressin is a neurohypophyseal hormone that includes antidiuresis, promotes glycogenolysis in the liver, and contracts vascular smooth muscle, thereby, raising blood pressure.
Ponnal Nambi   +2 more
openaire   +2 more sources

V2 vasopressin receptor mutations

2020
V2 vasopressin receptor (V2R) is a member of the G protein-coupled receptor (GPCR) family in which many disease-causing mutations have been identified and thus generated much interest. Loss-of-function V2R mutations cause nephrogenic diabetes insipidus (NDI) whereas gain-of-function mutations cause nephrogenic syndrome of inappropriate antidiuresis ...
Taroh Iiri   +4 more
openaire   +3 more sources

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