Results 331 to 340 of about 5,994,707 (387)
Some of the next articles are maybe not open access.
Cytokine & Growth Factor Reviews, 2001
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
Brain Research Reviews, 2008Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug dependence may substantially build on the existence of intramembrane receptor-receptor interactions within dopamine receptor containing receptor mosaics (RM; dimeric or high-order receptor oligomers ...
Fuxe K +14 more
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1992
Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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Reviews in the Neurosciences, 2016
AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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Receptor Regulation and Receptor-Receptor Communication
1987As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations.
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Bradykinin receptors and receptor ligands (with special emphasis on vascular receptors)
Regulatory Peptides, 1996Bradykinin and receptor ...
REGOLI, Domenico +7 more
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Pharmaceutica Acta Helvetiae, 2000
The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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Androgen Receptor and Estrogen Receptors
2002The androgen receptor (AR) and the estrogen receptors (ER) are members of the nuclear receptor (NR) family. These NRs are distinguished from the other transcription factors by their ability to control gene expression upon ligand binding (steroids, retinoids, thyroid hormone, vitamin D, fatty acids, and other small hydrophobic molecules). Their combined
H. M. Oosterkamp, R. Bernards
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Adenosine receptors: Intermembrane receptor–receptor interactions in the brain
Synergy, 2014Summary In the vertebrate central nervous system (CNS) the modulation of synaptic transmission by metabotropic or ionotropic receptors is an important source of control and dynamical adjustment in synaptic activity and can contribute to synergistic or antagonistic effects.
Karen Nieber, Sebastian Michael
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The thyrotropin receptor as a model to illustrate receptor and receptor antibody diseases
Baillière's Clinical Endocrinology and Metabolism, 1995The thyrotropin receptor (TSHR) has been used as an example to illustrate how disease may be the consequence of: 1. Modifications or inappropriate production of the natural ligand. 2. Production of abnormal agonists or antagonists such as autoantibodies. 3.
Ludgate, Marian, Vassart, Gilbert
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