Mapping Charge Interactions in Intrinsically Disordered Proteins
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips +14 more
wiley +1 more source
Explicit correction of severely non-uniform distributions of cryo-EM views. [PDF]
Barchet C +4 more
europepmc +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Reply to Peigneur et al. The Helix Ring Peptide U11 from the Venom of the Ant, Tetramorium bicarinatum, Acts as a Putative Pore-Forming Toxin, Not a New Kv1.3 Channel Blocker. Comment on "Boy et al. A New Kv1.3 Channel Blocker from the Venom of the Ant Tetramorium bicarinatum. Toxins 2025, 17, 379". [PDF]
Boy G +8 more
europepmc +1 more source
Encyclopaedia Cinematographica : Rapport sur l'Organisation actuelle de l'Encyclopédie du Film Scientifique [PDF]
Wolf, Gotthard
core
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research. [PDF]
Palermo TM +14 more
europepmc +1 more source
Monitoring New Technological Developments in the Electricity Industry : An International Perspective [PDF]
Being able to monitor and asses technological developments represents an essential activity for an industry expected to be increasingly active in all of the regions of the world and in markets which require a wide array of differing technological ...
Lise Préfontaine +2 more
core
A multi‐technique pump‐probe setup capable of performing both transient reflectivity and time‐resolved Raman spectroscopy after ultrafast excitation, provides a comprehensive understanding of ultrafast electronic and phononic processes. Distinct decay rates for the temperature, frequency, and linewidth of the phonon mode in germanium are observed ...
Grazia Raciti +10 more
wiley +1 more source

