Results 101 to 110 of about 521,476 (356)

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Pure distal 11q deletion without additional genomic imbalances in a female infant with Jacobsen syndrome and a de novo unbalanced reciprocal translocation

, 2012
[[abstract]]We report a neonate with pure deletion of distal 11q (11q23.3-->qter) and Jacobsen syndrome. The patient had growth restriction, petechiae, thrombocytopenia, dilation of renal pelvis, congenital heart defects, and seizures.
陳持平;Chen, Chih-Ping
core  

A Rare De Novo Reciprocal Translocation 46,XX,rec(7;13)(p22;q32) Karyotype

, 2021
Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities.
Elmas, Muhsin, Onrat, Serap Tutgun
core  

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

A Japanese case of chronic lymphocytic leukemia with t (1;6)

Experimental Hematology & Oncology, 2012
Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CLL.
Harada Kayo, Ikeda Kazuhiko, Matsumoto Hayato, Furukawa Miki, Takahashi Hiroshi, Ohkawara Hiroshi, Noji Hideyoshi, Tasaki Kazuhiro, Abe Masafumi, Ogawa Kazuei, Takeishi Yasuchika   +10 more
doaj   +1 more source

Supplementary Material for: De novo Subtelomeric Deletion Additional to an Inherited Apparently Balanced Reciprocal Translocation

, 2017
Objective: We describe the analysis of an apparently balanced inherited reciprocal translocation in a fetus presenting with multiple congenital abnormalities, characterize the structural chromosome rearrangement, and report an unexpected additional ...
Kanafani S. (4105882), Delahaye A. (4105879), Wolf J.P. (4105894), Vergnaud A. (4105897), Sinico M. (4105885), Gérard-Blanluet M. (4105891), Pipiras E. (4105876), Touboul C. (4105888), Encha-Razavi F. (4105906), Kasakyan S. (4105873), Serero S. (4105903), Benzacken B. (4105900), Benkhalifa M. (4105909)   +12 more
core   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from chromosome 18 and associated with a reciprocal translocation involving chromosomes 17 and 18

, 2012
[[abstract]]"Objective Prenatal diagnosis of small supernumerary marker chromosomes (sSMC) gives rise to difficulties in genetic counseling, and requires molecular cytogenetic technologies such as spectral karyotyping, fluorescence in situ hybridization,
陳持平;Chen, Chih-Ping;Lin, Chyi-Chyang;Su, Yi-Ning;Tsai, Fuu-Jen;Chen, Yu-Ting;Chern, Schu-Rern;Lee, Chen-Chi;Town, Dai-Dyi;Chen, Li-Feng;Wu, Pei-Chen;Wang, Wayseen
core  

Agronomic effects of a reciprocal translocation in a widely grown Spanish barley variety [PDF]

, 2012
A large spontaneous reciprocal translocation is present in a widely grown Spanish barley cv. ‘Albacete’. It has been hypothesized that high popularity of ‘Albacete’ with farmers, particularly in semi-arid areas where barley is grown under rainfed ...
Cistué, L., Romagosa, Ignacio, Lacasa-Benito, I., Cistué Sola, Luis, A. Visioni, I. Lacasa-Benito, Jansen, J., Farré, A., I. Romagosa, Visioni, A., A. Farré, J. Jansen, L. Cistué   +12 more
core   +1 more source