Results 141 to 150 of about 39,375 (245)

A Phenotypically Normal Homozygous Balanced Reciprocal Translocation Carrier: Report of an Extremely Rare Genetic Occurrence. [PDF]

Cureus
Thirupathy M, Shetty M, Prakash P.
europepmc   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, EarlyView.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

De novo translocation heterozygote with three reciprocal translocations. [PDF]

, 1983
J L Watt, D A Couzin
openalex   +1 more source

The epidemiology and pathogenesis of uterine fibroids

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Uterine fibroids, or leiomyomas, are the most common benign tumors of the female reproductive tract, ultimately affecting a majority of women worldwide, primarily during their reproductive years. While their origin appears genetic, manifesting in monoclonal tumors, diverse features and mechanisms contribute to their growth and further ...
Malcolm G. Munro, Svetlana N. Tchaikovski, Ally Murji   +2 more
wiley   +1 more source

Partial Trisomy of Chromosome 9 Inherited by Adjacent Segregation 2 of a Balanced Reciprocal Translocation in the Mother: Rare Mechanism in Chromosomal Abnormalities. [PDF]

Balkan J Med Genet
Zerrouki K, Aouni FE, Smaili F, Ahmidi J, Meziane S, Ahmidouch K, Tajir M.   +6 more
europepmc   +1 more source

Nutritional and Physiological Markers Are Mediated by Seasonality and Forest Access in Captive Coquerel's Sifakas 圈养科氏冕狐猴 (Coquerel's Sifakas) 的营养和生理指标受季节性和森林通道的影响

Integrative Conservation, EarlyView.
We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene, Laura N. Ellsaesser, Cathy V. Williams, Claudia Wrampelmeier, Anne D. Yoder, Marina B. Blanco   +5 more
wiley   +1 more source

Reciprocal translocation experiments reveal gut microbiome plasticity and host specificity in a Qinghai-Xizang Plateau lizard. [PDF]

Zool Res
Yu W, Yang J, Teng LW, Zhao XL, Zhu ZY, Cui S, Du WG, Liu ZS, Zeng ZG.   +8 more
europepmc   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Cytogenetically Balanced Reciprocal Translocation Could Hide Molecular Genomic Unbalances: Implications for Foetal Phenotype Correlation. [PDF]

Diagnostics (Basel)
Villa N, Redaelli S, Farina S, Sala E, Crosti F, Cozzolino S, Verderio M, Dalprà L, Roversi G, Bentivegna A, Cazzaniga G, Lavitrano M, Conconi D.   +12 more
europepmc   +1 more source