Results 251 to 260 of about 521,476 (356)

A Balanced Reciprocal Translocation t(2;9)(p25;q13) Disrupting the LINC00299 Gene in a Patient with Intellectual Disability. [PDF]

open access: yesMol Syndromol, 2019
Dornelles-Wawruk H   +8 more
europepmc   +1 more source

Ecology of reintroduced Rocky Mountain bighorn sheep in Dinosaur National Monument La Ecología de Borrego Cimarron de las Montañas Rocosas Reintroducido en el Monumento Nacional de Dinosaurio

open access: yesWildlife Monographs, EarlyView.
We synthesized GPS telemetry, genetic, and pathogen data to evaluate metapopulation processes in a reintroduced Rocky Mountain bighorn sheep (Ovis canadensis canadensis) population in Dinosaur National Monument. We estimated subpopulation‐specific abundances and found 4 small subpopulations with high genetic diversity, partial connectivity, and ...
Sarah L. Carroll   +8 more
wiley   +1 more source

The litter C/N ratio governs the dual role of ectomycorrhizal fungi in decomposition and plant nutrition absorption

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EcMF) modulate litter decomposition and facilitate nutrient acquisition through the soil–mycorrhiza–plant pathway. Although litter chemistry has been considered an important factor affecting litter decomposition, how it regulates EcMF‐induced ...
Yan Mei   +8 more
wiley   +1 more source

Climatic–Anthropogenic Synergy Drives Escalating Minimum Area Requirements and Connectivity‐Protection Mismatch in a Karst‐Endemic Primate

open access: yesIntegrative Zoology, EarlyView.
Climate change and anthropogenic activities drive antagonistic degradation of landscape connectivity for endangered François’ langur (1987–2024), causing 48.8% habitat loss, north‐south fragmentation, and centroid migration (1.2 km/yr). Despite protected areas buffering connectivity, static management fails dynamic priority habitats; we propose ...
Guangmei Yang   +5 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

open access: yesBritish Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu   +6 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

open access: yesBritish Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy