Results 71 to 80 of about 1,760,183 (325)

Homologous Pairing between Long DNA Double Helices

open access: yes, 2016
Molecular recognition between two double stranded (ds) DNA with homologous sequences may not seem compatible with the B-DNA structure because the sequence information is hidden when it is used for joining the two strands.
Mazur, Alexey K.
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

SSD-LeNet based method of mine moving target detection and recognition

open access: yes矿业科学学报, 2021
Aiming at the problems of low detection accuracy and low real-time performance in the detection and recognition of mine moving targets in foggy and low-illumination environment, a method based on deep convolutional neural network for intelligent ...
Zhang Fan   +3 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

An adaptive synthetic method for long sequence radar mode recognition

open access: yesIET Radar, Sonar & Navigation
Radar work mode recognition is crucial to analyse radar behaviour and intention. There are some challenges limiting the recognition of long sequences with multiple mode classes.
Xiaozhou Chen   +4 more
doaj   +1 more source

Attention-Based Models for Text-Dependent Speaker Verification

open access: yes, 2018
Attention-based models have recently shown great performance on a range of tasks, such as speech recognition, machine translation, and image captioning due to their ability to summarize relevant information that expands through the entire length of an ...
Chowdhury, F A Rezaur Rahman   +3 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Incorporation of local structural preference potential improves fold recognition. [PDF]

open access: yesPLoS ONE, 2011
Fold recognition, or threading, is a popular protein structure modeling approach that uses known structure templates to build structures for those of unknown.
Yun Hu   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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