Results 41 to 50 of about 4,040 (235)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Paths in first language acquisition: Motion through space in English, French and Japanese [PDF]
, 2005 This thesis examines how children attain the linguistic knowledge they need to grammatically express basic trajectories through physical space in English, French and Japanese.
Stringer, David
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Picture books written and illustrated by Lila Prap [PDF]
, 2015 Lilijana Praprotnik Zupančič, bolj znana pod umetniškim imenom Lila Prap, je pomembna ustvarjalka avtorskih slikanic, ki je za svoja dela prejela številne domače in tuje nagrade s področja mladinske književnosti.
Haramija, Dragica, Zupančič, Tomaž
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
NAME WRITING AND THE PRESCHOOL CHILD (LANGUAGE ACQUISITION, PREOPERATIONAL, CONSTRUCTION OF KNOWLEDGE, PIAGET). [PDF]
, 1985 This study explored the construction of written language knowledge as evidenced by the changes in forty-seven preschool children's autographs. Throughout the school year children were asked to "write your name and draw a picture of yourself." The ...
LIEBERMAN, EVELYN JACKSON.
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Super Apocalypto 64: Inhabiting Revelation as a Video Game Made of Sacred Words [PDF]
, 2022 The book of Revelation makes the living and life-giving reality of Scripture known to audiences via the vision articulated by John. He conveys this divine reality through words – both read and heard – which call for more than the passive reception of a ...
Jones, Greg
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Analyse, Katalogisierung und spielpädagogische Bewertung von „Alle Arten von Scherz- und Pfänderspielen in lustigen Compagnien“ [PDF]
, 2020 Bei diesem Spielbuch handelt es sich um die Erstausgabe, die um etwa 1750 anzusetzen ist. Damit ist es das erste deutschsprachige Gesellschaftsspielbuch überhaupt. In der vorliegenden Publikation werden die Hintergründe der Gesellschaftsspiele beleuchtet
Buland, Rainer
core +1 more source