Results 201 to 210 of about 399,275 (342)

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Flagellin as a Versatile Adjuvant Platform: Genetic Fusion Approaches for Next-Generation Vaccines. [PDF]

Int J Mol Sci
Mardanova ES, Ravin NV.
europepmc   +1 more source

Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO-Fc Fusion Protein In Vivo

, 2013
Xunlong Shi, Jianjun Yang, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Huang, Qun Tao, Dan Ye, Lee-Hwei K. Sun, Bill N. C. Sun, Cecily R. Y. Sun, Gui‐Zhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou, Dianwen Ju   +16 more
openalex   +2 more sources

Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model [PDF]

, 2002
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun G. Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang   +7 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

A High-Throughput Multi Well Plate-Based Approach for the Combined Expression, Export, and Assay of Recombinant Proteins. [PDF]

Curr Protoc
Baker K, Mulvihill DP.
europepmc   +1 more source

Active immunization of Japanese quail hens with a recombinant chicken inhibin fusion protein enhances production performance

, 1998
J.D. Moreau, DG Satterlee, JJ Rejman, GG Cadd, Konstantin G. Kousoulas, W.C. Fioretti   +5 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

In vitro synthesis of active recombinant orthoflavivirus nonstructural polyproteins in detergent micelles for biochemical analysis. [PDF]

Npj Viruses
Takahashi H, Uchiage Y, Emura Y, Yamagami R, Abe M, Yoshii K, Tajima S, Lim CK, Hori H, Vasudevan SG, Sawasaki T.   +10 more
europepmc   +1 more source

Long‐acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B‐LONG study [PDF]

, 2014
Jerry S. Powell, Shashikant Apte, Hérvè Chambost, Cédric Hermans, Shannon Jackson, Neil C. Josephson, Johnny Mahlangu, Margareth C. Ozelo, Kathelijne Peerlinck, John Pasi, David J. Perry, Margaret V. Ragni, Xuefeng Wang, Haiyan Jiang, Shuanglian Li, Lynda M. Cristiano, Alison Innes, Karen Nugent, Aoife M. Brennan, Alvin Luk, Geoffrey Allen, Glenn F. Pierce, Brian Robinson   +22 more
openalex   +1 more source