Correction: Subcutaneous application of hyperimmune serum against Histophilus somni recombinant proteins affects serum antibody reactivity in beef calves. [PDF]
BMC Vet ResBajzert J +3 more
europepmc +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
Advanced Science, EarlyView.This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang +14 more
wiley +1 more source
The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ
Advanced Science, Volume 12, Issue 15, April 17, 2025.The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo +17 more
wiley +1 more source
The dangerous liaisons in innate immunity involving recombinant proteins and endotoxins: Examples from the literature and the Leptospira field. [PDF]
J Biol ChemBonhomme D, Cavaillon JM, Werts C.
europepmc +1 more source
Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and cryptococcal species [PDF]
, 2017 et al,, Lodge, Jennifer K
core +1 more source
Advanced Science, EarlyView.Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang +14 more
wiley +1 more source
Subcutaneous application of hyperimmune serum against Histophilus somni recombinant proteins affects serum antibody reactivity in beef calves. [PDF]
BMC Vet ResBajzert J +3 more
europepmc +1 more source
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation
Advanced Science, Volume 12, Issue 15, April 17, 2025.This article studies the role of UFMylation in NLRP3 inflammasome activation. It reveals that UFMylation, mediated by the E3 Ufm1‐ligase 1 (Ufl1), maintains NLRP3 stability by preventing its ubiquitination and subsequent autophagic degradation.
Jiongjie Jing +14 more
wiley +1 more source
Multi‐Omics Analysis Reveals Impacts of LincRNA Deletion on Yeast Protein Synthesis
Advanced Science, Volume 12, Issue 13, April 3, 2025.This study demonstrates that the deletion of specific lincRNAs in yeast affects protein secretion. An engineered yeast strain, with multiple genetic modifications including lincRNA deletion, achieves a high yield of 4.1 g L⁻1 in fed‐batch cultivation.
Ling Qin +8 more
wiley +1 more source