Results 211 to 220 of about 501,800 (253)
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Initiation of genetic recombination and recombination-dependent replication
Trends in Biochemical Sciences, 2000Recombination initiates at double-stranded DNA breaks and at single-stranded DNA gaps. These DNA strand discontinuities can arise from DNA-damaging agents and from normal DNA replication when the DNA polymerase encounters an imperfection in the DNA template or another protein.
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Recombinant proteins for genetic disease
Clinical Genetics, 1999The era of molecular biology has led to the development of powerful tools capable of generating therapeutics for genetic disorders. Although there is much current emphasis placed on the development of ‘gene therapy’ for human disease, developments in the production and availability of recombinant proteins are likely to have a more substantial impact on
Christopher S. Russell, Lorne A. Clarke
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The Theory of Genetical Recombination
1950Publisher Summary The aim of genetical research is to determine the topography of the genetical material in various organisms and to represent the mutable genes on each chromosome as occupying positions on a linear map. The order and spacing of the genes in the main has to be inferred from the amounts of recombination exhibited by sets of genes when ...
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Evidence of genetic recombination in Leishmania
Molecular and Biochemical Parasitology, 1991In the genus Leishmania there has been no convincing demonstration of genetic exchange, and it has been proposed that reproduction is clonal. However, preliminary characterization of two strains of Leishmania isolated from wild animals in a zoonotic focus of cutaneous leishmaniasis in the Eastern Province of Saudi Arabia, has suggested that they may ...
John M. Kelly +4 more
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Genetic recombination in avian retroviruses
Journal of Cellular Biochemistry, 1982AbstractThe avian retroviruses—and probably other retroviruses as well—undergo a variety of recombinational events with relatively high efficiency. An understanding of the molecular basis of these events should provide insight into the important biological properties these agents exhibit when they become integrated into somatic or germ‐line host cells,
Richard P. Junghans +3 more
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MOLECULAR MECHANISMS IN GENETIC RECOMBINATION [PDF]
Annual Review of Genetics, 1973 Genetic recombination is the set of processes that results in new linkage relationships of genes or parts of genes (l), Three subclasses of recombination are currently recognized: (a) General recombination describes exchanges that occur between homologous genophores, more or less anywhere along their length.
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Group representation of genetic recombinations
The Bulletin of Mathematical Biophysics, 1964An algebraic representation of operations of genetic recombinations is illustrated. It is shown that the recombinations between chromosomes in the two-strand model can be represented by groups, in the sense of the theory of groups. Recombinations between chromosomes with inversions and a translocation are considered as well as cases without them. It is
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Genetic control of intrachromosomal recombination
BioEssays, 1995AbstractIntrachromosomal recombination between direct repeats can occur either as gene conversion events, which maintain exactly the number of repeat units, or as deletions, which reduce the number of repeat units. Gene conversions are classical recombination events that utilize the standard chromosome recombination machinery.
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1993
The application of genetic algorithms to optimisation problems for which the solution is a set or multiset (bag) is considered. A previous extension of schema analysis, known as forma analysis, is further developed and used to construct principled representations and operators for problems in this class.
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The application of genetic algorithms to optimisation problems for which the solution is a set or multiset (bag) is considered. A previous extension of schema analysis, known as forma analysis, is further developed and used to construct principled representations and operators for problems in this class.
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Genetic recombination in malaria parasites
Experimental Parasitology, 1989In this review, results of crossing studies are discussed with particular reference to recent work on parasite chromosome variation, as revealed by pulsed field gradient gel electrophoresis (PFG)
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