Results 31 to 40 of about 70,103 (68)
Identification of IspD as a novel target for tuberculosis treatment using compound M6 [PDF]
IntroductionTuberculosis (TB) is a serious infectious disease that endangers human health, and TB becomes more difficult in eradiation due to its multidrug resistance (MDR).
Yue Zhu +10 more
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Pseudilins : halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD
, 2014 The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis have been identified as attractive targets with novel modes of action for the development of herbicides for crop protection and agents against infectious diseases.
Michael Groll +25 more
core +1 more source
Simulação de sistemas de computação em nuvem para o iSPD
, 2015 O uso de computação em nuvem tem se tornado cada vez mais intenso nos últimos anos. Devido principalmente a fatores econômicos, a avaliação de desempenho de sistemas de computação em nuvem, principalmente através de simulação, tem sido amplamente ...
Spolon, Roberta +5 more
core +1 more source
Reengineering workload management at iSPD
A Computação de Alta Performance (HPC) é essencial para resolver problemas complexos no âmbito cientifico, médico ou comercial. As grades computacionais são uma ótima solução para a HPC, fazendo com que diversas ferramentas que simulam essa ...
Oliveira Filho, Marcelo Ferreira de [UNESP]
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Design, synthesis, and evaluation of inhibitors of IspD and IspE as potential antibacterial, antimalarial, and herbicidal agents [PDF]
, 2015 The 2-C-methyl-D-erythritol-4-phosphate pathway, or MEP pathway, has recently gained attention as being a prime target for inhibition of many pathogenic species due to the lack of analogous enzymes in humans and many higher eukaryotes that use the ...
Thompson, Michael Philip
core +1 more source
Limb-girdle muscular dystrophy with α-dystroglycan deficiency and mutations in the ISPD gene
, 2013 Defects in the posttranslational modification of α-dystroglycan (α-DG) have been implicated in clinically distinct dystroglycanopathies that present as congenital muscular dystrophies with multisystem involvement, limb-girdle muscular dystrophies (LGMDs),
Ricci, Enzo, Tasca, Giorgio
core +1 more source
, 2017 Les termes de référence de cette expertise collégiale placent la question des recommandations au centre de la commande, bien loin de l’exercice un peu rituel et à la portée limitée auquel se réduit parfois le jeu des recommandations.
core +1 more source
Antimicrobial resistance (AMR) and herbicide resistance pose threats to society, necessitating novel anti-infectives and herbicides exploiting untapped modes of action like inhibition of IspD, the third enzyme in the MEP pathway.
Diamanti, Eleonora +3 more
core +1 more source
, 2014 The non-mevalonate pathway is present in most pathogenic bacteria, the causative agent of malaria, as well as plants, but is absent in mammals. The enzymes of this pathway are therefore perfectly suited for the development of antiinfectives.
Kunfermann, Andrea Christiana
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