Results 111 to 120 of about 23,764 (310)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Survey on the applications of large language models in recommender systems

大数据
The rise of large language model (LLM) has brought new opportunities to recommender systems. However, existing research mainly focuses on the technical frameworks and engineering implementations of LLM-based recommender systems, lacking a systematic ...
Xu Xiaoying, Liao Wenjie, Wang Hanlin
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Systematic Literature Review on Recommender System: Approach, Problem, Evaluation Techniques, Datasets

IEEE Access
Recommender systems become essential with the presence of the internet and social media. The perceived benefits of the recommender system can make it easier for users to find suitable products and recommend other products, specifically with lots of ...
Ilham Saifudin, Triyanna Widiyaningtyas
doaj   +1 more source

Recommender Systems for the Semantic Web

, 2006
This paper presents a semantic approach to Recommender Systems (RS), to exploit available contextual information about both the items to be recommended and the recommendation process, in an attempt to overcome some of the shortcomings of traditional RS ...
Loizou, Antonis, Dasmahapatra, Srinandan
core  

Bandit Algorithms for e-Commerce Recommender Systems

, 2017
We study bandit algorithms for e-commerce recommender systems. The question we pose is whether it is necessary to consider reinforcement learning effects in recommender systems.
Bengt J. Nilsson, Brodén, Björn,, Nilsson, Bengt J.,, Hammar, Mikael,, Mikael Hammar, Dimitris Paraschakis, Björn Brodén, Paraschakis, Dimitris,   +7 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Modern Approaches to Building Recommender Systems for Online Stores

Applied Computer Systems, 2019
The article presents current approaches to solving the problem of building recommender systems designed to intellectualize the user interface of online stores.
Onokoy Lyudmila, Lavendels Jurijs
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source