Results 61 to 70 of about 3,968,079 (328)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context [PDF]

BMC Bioinformatics, 2004
BackgroundElucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for ...
Adam A. Margolin, I. Nemenman, K. Basso, C. Wiggins, G. Stolovitzky, R. Favera, A. Califano   +6 more
semanticscholar   +1 more source

Weakly supervised 3D Reconstruction with Adversarial Constraint

, 2017
Supervised 3D reconstruction has witnessed a significant progress through the use of deep neural networks. However, this increase in performance requires large scale annotations of 2D/3D data.
Chandraker, Manmohan, Choy, Christopher B., Garg, Animesh, Gwak, JunYoung, Savarese, Silvio   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Heat generation and histological analysis of peri-implant bone cutting using piezoelectric surgery for implant removal: an in vitro study

International Journal of Implant Dentistry
Purpose This study aimed to evaluate the safety of piezoelectric surgery for bone cutting during implant removal in terms of heat generation and histological changes.
Yoshiki Saito, Hiroki Tsukamoto, Kiyoshi Shimada, Yusuke Kondo, Keiko Kiyomura, Tomotaka Nodai, Takashi Munemasa, Taro Mukaibo, Ryuji Hosokawa, Chihiro Masaki   +9 more
doaj   +1 more source

The Importance of Length of the Cephalomedullary Nails for Fixation of the Proximal Femoral Fractures: An Educational Corner

Journal of Orthopedic and Spine Trauma, 2021
No abstract is available.
Moein Khoori, Alireza Moharrami, Nima Hoseini Zare, SM Javad Mortazavi   +3 more
doaj   +1 more source

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

Nature Methods, 2019
Cryogenic electron microscopy (cryo-EM) is widely used to study biological macromolecules that comprise regions with disorder, flexibility or partial occupancy.
A. Punjani, H. Zhang, David J. Fleet
semanticscholar   +1 more source

Reconstruction of potential energy profiles from multiple rupture time distributions

, 2010
We explore the mathematical and numerical aspects of reconstructing a potential energy profile of a molecular bond from its rupture time distribution.
Dudko O. K., Freund L. B., Keller H. B.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Early-stage reconstruction of flexor pollicis longus using palmaris longus in a patient with compartment syndrome of forearm: a case report

Journal of Medical Case Reports, 2022
Background The flexor pollicis longus is the most vulnerable muscle in acute compartment syndrome of the forearm. Reconstruction of a dysfunctional flexor pollicis longus is occasionally necessary following compartment syndrome of the forearm.
Muneyoshi Fujita, Hideaki Miyamoto, Taketo Kurozumi   +2 more
doaj   +1 more source