Results 51 to 60 of about 56,768,445 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oxidative Stress in Postbariatric Patients: A Systematic Literature Review Exploring the Long-term Effects of Bariatric Surgery

open access: yesPlastic and Reconstructive Surgery, Global Open
Background:. The present study investigates the impact of oxidative stress after bariatric surgery in patients with obesity. This field of study has gained great interest in recent years due to the role that oxidative stress plays in metabolic diseases ...
Jessica Juliana Pradel-Mora, MD   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Scottish Social Attitudes Survey, 2014

open access: yes, 2014
copyright UK Data Service and data collection copyright owner.The Scottish Social Attitudes (SSA) survey was launched by ScotCen Social Research (formerly the Scottish Centre for Social Research) in 1999, following the advent of devolution.
ScotCen Social Research
core   +3 more sources

Review: Ralf Bohnsack, Aglaja Przyborski & Burkhart Schäffer (Eds.) (2006). Das Gruppendiskussionsverfahren in der Forschungspraxis [Group Discussions in Research Practise]

open access: yesForum: Qualitative Social Research, 2007
This anthology by BOHNSACK, PRZYBORSKI and SCHÄFFER promises insights into concrete models of group discussions in specific fields of research (such as infancy, adolescence, and actual applications in organizational and social contexts). It also offers a
Daniela Jauk
doaj  

Reconstructive Social Research Prompting. Distributed Interpretation between AI and Researchers in Qualitative Research

open access: yes
This article explores the intersection of artificial intelligence (AI) and reconstruc-tive qualitative social research, examining how large language models (LLMs) can aid in interpreting empirical data, such as data from interviews or group discussions.
Fabio Roman Lieder, Burkhard Schäffer
openaire   +1 more source

"Qualitative" Methods of Social Research in France: Reconstructing the Actor, Deconstructing the Subject

open access: yesForum: Qualitative Social Research, 2005
This contribution gives an overview of the numerous tendencies of open non-standardised social research in France. For various reasons, the label "qualitative" seems to be less distinctive than in the Anglo-Saxon world and Germany. While the interpretive-hermeneutic (verstehend) ap­proa­ches have recently come to play a certain role as a result of ...
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

HRM 4.0 and New Managerial Competences Profile: The COMAU Case

open access: yesFrontiers in Psychology, 2020
The digital revolution has generated huge changes in the world of work, with relevant implications for the Human Resources Management (HRM) function. New challenges arise in facing digital work, digital employees, and digital management, such that the ...
Ezio Fregnan   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

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