Results 81 to 90 of about 375,817 (354)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Choquet integral for record linkage

Annals of Operations Research, 2011
Record linkage is used in data privacy to evaluate the disclosure risk of protected data. It models potential attacks, where an intruder attempts to link records from the protected data to the original data. In this paper we introduce a novel distance based record linkage, which uses the Choquet integral to compute the distance between records.
Abril, Daniel, Navarro-Arribas, Guillermo, Torra, Vicenç   +2 more
openaire   +3 more sources

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Performance Evaluation and Accuracy Improvement in Individual Record Linking Problems Using Decision Tree Algorithm in Machine Learning [PDF]

Iranian Journal of Information Processing & Management
Record linkage is a vital process for consolidating data from different sources, particularly in Persian records where diverse data structures and formats present challenges. To tackle these complexities, an expert system with decision tree algorithms is
Vadood Keramati, Ramin Sadeghian, Maryam Hamedi, Ashkan Shabbak   +3 more
doaj   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Record linkage is feasible with non‐identifiable trauma and rehabilitation datasets

Australian and New Zealand Journal of Public Health, 2016
Objectives: 1) Describe probabilistic linkage (PL) for road trauma and rehabilitation records in New South Wales (NSW) Australia. 2) Determine the accuracy of linkage for these records.
Jane Wu, Steven G. Faux, Ian Harris, Christopher J. Poulos, Tara Alexander   +4 more
doaj   +1 more source

Implementing privacy-preserving record linkage: welcome to the real world

International Journal of Population Data Science, 2017
Objectives While record linkage has become a strategic research priority within Australia and internationally, legal and administrative issues prevent data linkage in some situations due to privacy concerns.
James Boyd, Anna Ferrante, Adrian Brown, Sean Randall, James Semmens   +4 more
doaj   +1 more source

Quality of record linkage in a highly automated cancer registry that relies on encrypted identity data [PDF]

, 2016
Objectives: In the absence of unique ID numbers, cancer and other registries in Germany and elsewhere rely on identity data to link records pertaining to the same patient. These data are often encrypted to ensure privacy.
Borg, Andreas, Gerold-Ay, Aslihan, Hammer, Gaël Paul, Heidinger, Oliver, Hense, Hans-Werner, Krieg, Volker, Sariyar, Murat, Schmidtmann, Irene   +7 more
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source