The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Comparison of Modified Constraint-Induced Movement Therapy (mCIMT) Hand Arm Bimanual Intensive Training and Mirror Therapy to Improve Upper Extremity Function in Children with Hemiplegic Cerebral Palsy: A Double-blinded Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Hemiplegic Cerebral Palsy (CP), a non-progressive neurological disorder resulting from early brain injury, leads to unilateral motor deficits, predominantly impacting Upper Extremity (UE) function.
Rahul Bisen, Suvarna Ganvir
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Micronutrient Status and the Predictors of Recovery Time in Children with Severe Acute Malnutrition: A Prospective Observational Study [PDF]
Indian Journal of Neonatal Medicine and ResearchIntroduction: Severe Acute Malnutrition (SAM) remains a major cause of child mortality worldwide. Understanding the determinants of recovery time in children with SAM is pivotal for reducing associated mortality and morbidity.
Anusha Chelladurai +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Algorithm of determination of the volume of surgical intervention in athletes with Haglund deformity
Спортивная медицина: наука и практика, 2020 Objective: to develop an algorithm for determining the extent of surgical intervention for pain in the heel region based on a comprehensive clinical and instrumental assessment of the functional state of the lower extremities.
M. N. Velichko +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke
Frontiers in Molecular NeuroscienceMicroglia and astrocytes play an important role in the neuroinflammatory response and contribute to both the destruction of neighboring tissue as well as the resolution of inflammation following stroke. These reactive glial cells are highly heterogeneous
Kimberly Prescott +12 more
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