Results 41 to 50 of about 1,643,373 (376)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Methodology of recreation in the structure of educational space. [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011 The article deals with the methodological aspects of health, healthy lifestyle and recreation, touching students in higher educational establishments.
Zaytzev V.P. +2 more
doaj
New Zealand outdoor recreation benefits [PDF]
, 2007 Millions of people participate in outdoor recreation activities in New Zealand every year. Economic recreation studies in the country concentrate mostly on market values. Market values only present part of the outdoor recreation benefit; while non-market
Kaval, Pamela, Yao, Richard
core +1 more source
Forests, 2019 Providing memorable tourism experiences (MTEs) plays a crucial role in determining the competitiveness and sustainability of a destination for not only the business sector, but also the environment.
Chia-Pin Yu +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Use of Multiple Methods: An Examination of Constraints Effecting Ethnic Minority Visitor Use of National Parks and Management Implications [PDF]
, 2008 Understanding outdoor recreation participation and national park visitation by members of ethnic minority groups has been a particular focus of outdoor recreation researchers for the past twenty years.
Roberts, Nina S., Rodriguez, Donald A.
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Recreation Benefits of U.S. Parks [PDF]
, 2007 Over 90 percent of people living in the United States participate in some type of outdoor recreation, from walking the dog to rock climbing. These activities increase a person’s well-being and are examples of recreation benefits.
Kaval, Pamela
core +1 more source
Wolverines in winter: indirect habitat loss and functional responses to backcountry recreation
Ecosphere, 2019 . Outdoor recreation is increasingly recognized to impact nature and wildlife, yet few studies have examined recreation within large natural landscapes that are critical habitat to some of our most rare and potentially disturbance-sensitive species. Over
Kimberly S. Heinemeyer +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source