Results 41 to 50 of about 1,519,467 (331)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Green physical activity for leisure connects perceived residential greenspace and mental well-being
Frontiers in Public Health, 2023 Physical activity serves as a pivotal mediator in previous theoretical frameworks that link greenspace and human health. However, it remains unclear whether the domain of physical activity within and around greenspaces can alter the pathway.
Hansen Li +3 more
doaj +1 more source
Involvement of Park and Recreation Professionals in Pedestrian Plans [PDF]
, 2009 Professionals from many different disciplines are finding innovative ways to work together to increase physical activity to help create healthier communities.
Aytur, Semra +3 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
The research landscape of direct, sensory human–nature interactions
People and Nature, 2023 Gaining a comprehensive understanding of the human–nature interactions research landscape can benefit researchers by providing insights into the most relevant topics, popular research areas and the distribution of topics across different disciplines ...
Maldwyn J. Evans +3 more
doaj +1 more source
Recreation Benefits of U.S. Parks [PDF]
, 2007 Over 90 percent of people living in the United States participate in some type of outdoor recreation, from walking the dog to rock climbing. These activities increase a person’s well-being and are examples of recreation benefits.
Kaval, Pamela
core +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Physical activity and active recreation before and during COVID-19: The Our Life at Home study [PDF]
, 2021 Lauren Arundell +8 more
openalex +1 more source
Use of Multiple Methods: An Examination of Constraints Effecting Ethnic Minority Visitor Use of National Parks and Management Implications [PDF]
, 2008 Understanding outdoor recreation participation and national park visitation by members of ethnic minority groups has been a particular focus of outdoor recreation researchers for the past twenty years.
Roberts, Nina S., Rodriguez, Donald A.
core +2 more sources