Results 251 to 260 of about 278,155 (336)

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

Satisfaction of Nurses Regarding Workplace Facilities in a Tertiary Hospital. [PDF]

SAGE Open Nurs
Shipa MFE, Akhtar K, Sanda SA, Bose L, Ara B.   +4 more
europepmc   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Triaging in Mass Casualty Incidents: A Simulation-Based Scenario Training for Emergency Care Senior Residents. [PDF]

Clin Teach
Rotzoll D, Pott C, Stöhr R, Hartwig T, Gries A.   +4 more
europepmc   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

The Determinants of Bone Health in Children With Autism Spectrum Disorder: A Systematic Narrative Review. [PDF]

J Paediatr Child Health
Lipszyc RT, Rodda CP, Wright M, Duckham RL.   +3 more
europepmc   +1 more source

Capacity of Social Institutions: Towards Participation in Community-Centered Management Programs. [PDF]

Int J Prev Med
Heidarzadeh A, Farrokhi M, Bazyar J, Pourvakhshoori N.   +3 more
europepmc   +1 more source

Community Stakeholders' Perspectives on Recruiting Young Adolescents (Age 10-14) in Sexual Health Research. [PDF]

Healthcare (Basel)
Muheriwa Matemba SR, Abboud S, Jeremiah RD, Crooks N, Alcena-Stiner DC, Collen LY, Zimba CC, Castellano C, Evans AL, Johnson D, Harris T, LeBlanc NM.   +11 more
europepmc   +1 more source

Factors influencing sustainable development in Eco-tourism settlements: A comparative analysis. [PDF]

Heliyon
Habibulloev S, Han F, Bakhtiyorov Z, M A X, Nuhzor O.   +4 more
europepmc   +1 more source