Results 241 to 250 of about 547,648 (312)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Percutaneous Endovascular Extraction of a Fractured Central Line Catheter From the Intracardiac Space Utilizing a Snare: A Case Report. [PDF]

Cureus
Pande A, Debbarma D, Samanta A, Das S, Datta S.   +4 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

A Comparison of the Psychometric Properties of PROMIS Computer Adaptive Tests and Short Forms Vs Legacy Patient-Reported Outcome Measures in Total Knee Arthroplasty Patients. [PDF]

Arthroplast Today
Braaksma C, Wolterbeek N, Veen MR, Poolman RW, Pronk Y, Rasker AJ, Ostelo RWJG, Terwee CB.   +7 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

The Wolverine Project: Evaluating Cumulative Effects Within the Land of Ktunaxa Using the One Heart Method. [PDF]

Environ Manage
Heim N, MacDonald R, Horsethief C, Luke C, Proctor M, Machmer M, Birdstone V, Warden R, Wullum C, Plewes R, Chernos M, Carlson M.   +11 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

High posterior tibial slope is associated with higher failure rates in nonoperative management of primary anterior cruciate ligament injury. [PDF]

J Exp Orthop
Heidecke S, Kraml N, Haslhofer D, Schwarz PM, Gotterbarm T, Winkler PW.   +5 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Feasibility and Acceptability of a Community and Family-Based Fitness and Healthy Lifestyle Program Among Latino Families: The Athletes for Life Program. [PDF]

Am J Lifestyle Med
Vargas Tequida B, Vega-López S, Flórez-Pregonero A, Todd M, Ray F, Shaibi GQ, Crespo NC.   +6 more
europepmc   +1 more source