Results 31 to 40 of about 4,360,620 (315)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Environmental awareness influences the perception of ecosystem services values at Lake Balaton, Hungary [PDF]

One Ecosystem
Knowing people’s perceptions on the importance and value of ecosystem services (ES) is an important step towards sustainable management and recognised as essential for successful conservation. We assessed societal preferences, i.e.
Ágnes Vári, Diána Berecz, Bence Fülöp, Márk Honti, Tibor Erős   +4 more
doaj   +3 more sources

Metabolomic Detection Between Pancreatic Cancer and Liver Metastasis Nude Mouse Models Constructed by Using the PANC1-KAI1/CD Cell Line

Technology in Cancer Research & Treatment, 2021
Background: Pancreatic cancer (PC) has a poor prognosis and is prone to liver metastasis. The KAI1/CD 82 gene inhibits PC metastasis. This study aimed to explore differential metabolites and enrich the pathways in serum samples between PC and liver ...
Shuo Wang PhD, Jiang Chen PhD, Hongyu Li PhD, Xingshun Qi PhD, Xu Liu PhD, Xiaozhong Guo PhD   +5 more
doaj   +1 more source

Recreating Cultural Immersion in an On-Line Environment

Journal of Teaching and Learning with Technology, 2021
The Covid19 Pandemic threw a curve ball into everyone’s Spring teaching schedule. But for those of us who were a week away from taking their students overseas, it was a game changer. How do you create make up material for 1.5 credit hours while staying true to the course objective of “understanding another culture through immersion and interaction?” My
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The actual knee function was not influenced by joint line obliquity after open-wedge high tibial osteotomy

SICOT-J, 2020
Purpose: Excessive joint line obliquity (JLO) after open-wedge high tibial osteotomy (OWHTO) induces detrimental stress on the articular cartilage. The purpose of this article is to assess the correlation between JLO and the clinical results after OWHTO.
Kubota Mitsuaki, Kim Youngji, Sato Taisuke, Yamaguchi Junichiro, Ohno Ryuichi, Kaneko Kazuo, Ishijima Muneaki   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

THE ICONOGRAPHIC COLOUR SYMBOLISM IN BIBLICAL POEMS BY SERGEI YESENIN [PDF]

Проблемы исторической поэтики, 2014
The Biblical poems by Sergei Yesenin are full of pathos of theurgic reforms and creation of a new world. All components of these poems (images, spatial-temporal organization, colour symbolics) stressed the importance of ongoing changes. The colours in
Natalia Vladimirovna Mikhalenko
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Farklı Beton Dayanımlarındaki Kolonlarda, Eksenel Yük Seviyelerine Göre Geri Sıçramalı Çekiç Verilerinin Korelasyonu İçin Deneysel Bir Öneri

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Betonun basınç dayanımı, betonarme sistemin yapısal bütünlüğü açısından hayati önem taşımaktadır. Gerek inşaat aşamasında gerekse inşaat tamamlandıktan sonra, farklı yapı elemanlarındaki basınç dayanımlarının bilinmesi, kontrol ve değerlendirme ...
Yusuf Demirel
doaj