Results 31 to 40 of about 542,624 (334)
Abuse potential of mirogabalin in recreational polydrug users [PDF]
Therapeutic Advances in Drug Safety, 2019 Mirogabalin is a selective calcium channel α2δ subunit ligand being developed to treat neuropathic pain. In accordance with US Food and Drug Administration (FDA) guidance, the human abuse potential of mirogabalin (15–105 mg) was examined, relative to placebo, diazepam (15 or 30 mg), and pregabalin (200 or 450 mg), in two single-dose, randomized ...
Jeanne Mendell +7 more
openaire +3 more sources
Global drivers and tradeoffs of three urban vegetation ecosystem services. [PDF]
PLoS ONE, 2014 Our world is increasingly urbanizing which is highlighting that sustainable cities are essential for maintaining human well-being. This research is one of the first attempts to globally synthesize the effects of urbanization on ecosystem services and how
Cynnamon Dobbs +2 more
doaj +1 more source
Ecosystem services accounting: Part I - Outdoor recreation and crop pollination [PDF]
, 2017 The Knowledge Innovation Project on an Integrated system of Natural Capital and ecosystem services Accounting (KIP INCA) aims to develop the first ecosystem accounts at EU level, following the UN System of Environmental-Economic Accounting- Experimental ...
ALEXANDRIS NIKOLAOS +6 more
core +2 more sources
Современная наука и инновации, 2022 The work discusses about the methods of estimation of anthropogenic influence on recreation potential of region of the Caucasian Mineral Waters. Integral indicator of sustainable development can be calculated on the basis on the individual indicators of ...
Tatyana Alexandrovna Shebzukhova +2 more
doaj
Recreation potential of agro-tourism
Scientific Messenger of LNU of Veterinary Medicine and BiotechnologiesThe article examines the essence of recreational potential, in particular in the context of agrotourism, taking into account the needs of vacationers and the proposed agrotourism product. The concept and meaning of recreation, as a way of meeting the relevant needs of a person and improving the quality of his life, the differences between the ...
N. Lypchuk, V. Lypchuk
openaire +1 more source
Benefits of crowd-sourced GPS information for modelling the recreation ecosystem service. [PDF]
PLoS ONE, 2018 Modelling cultural ecosystem services is an enduring challenge, raising issues about the integration and spatialization of immaterial values and benefits, and their contingency on local preferences.
Coline Byczek +3 more
doaj +1 more source
Organizationally-economic ground of nature recreation potential of the territory [PDF]
, 2007 In the conditions of difficult transformations processes which take place in Ukraine, the special actuality is acquired by the problem of development of recreation sphere, which is the base of realization of rights and necessities of man in the system of
Shevchenko, Hanna Mykolaivna +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Expansion of urban recreation areas as a factor for human capital renovation
MATEC Web of Conferences, 2018 The paper is focused on the development of urban space on the basis of the modern urban development concepts. The role of urban environment in the development of individuals, their physical, intellectual and spiritual potential is described with the use ...
Ovsiannikova Tatiana +2 more
doaj +2 more sources