Results 41 to 50 of about 542,624 (334)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Assessing the recreational potential of Lake Eğirdir and its surroundings land use recommendations based on the Gülez Method

Turkish Journal of Forestry
This study aims to assess the recreational potential of Lake Eğirdir and its surroundings in Isparta province and to develop land use recommendations for more efficient use of these areas. The “Forest Recreation Potential Determination” method, developed
Hazal Ezgi Gündüz
doaj   +1 more source

Involvement of Park and Recreation Professionals in Pedestrian Plans [PDF]

, 2009
Professionals from many different disciplines are finding innovative ways to work together to increase physical activity to help create healthier communities.
Aytur, Semra, Evenson, Kelly R, Rodriguez, Daniel A, Salveson, David   +3 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Isparta Gölcük Tabiat Parkının Rekreasyon Potansiyelini Belirlemeye Yönelik Bir Araştırma

Düzce University Faculty of Forestry Journal of Forestry
Sanayi Devrimi'nin ardından, artan iş yoğunluğu ve hızlı nüfus artışı, bireylerin kentlerde yoğunlaşmasına neden olmuştur. Bu yoğunluk, bireylerin hem zihinsel hem de fiziksel sağlıklarını olumsuz yönde etkilemektedir.
Büşra Kutlu, Sarıyya Rahımbaylı, Mert Akoğlu   +2 more
doaj   +1 more source

SETTLEMENT UPRAVLENCHESKY: HISTORY AND RECREATIONAL POTENTIAL

Innovative Project, 2019
The potential of the territories of the northern settlements of the city of Samara, located along the Volga River in the Krasnoglinsky district, is analyzed from the standpoint of the development of public and recreational spaces in this part of the city. Specifically, the territory of the Upravlenchesky settlement is examined, their role in the system
Tatiana Vyacheslavovna Filanova, Vasily Dmitrievich Filippov, Anna Ekaterinskaya   +2 more
openaire   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

EXPERIMENTAL WORK ON PEDAGOGIC POTENTIAL FOUNDATION OF LEISURE AND HEALTH-GIVING TECHNOLOGIES IN ORGANIZATION OF HEALTH-RELATED REST FOR THE YOUNGER GENERATION

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2016
The experimental work is carried out to substantiate the pedagogical potential of recreational and health technologies in organization of medical-improving rest of the younger generation.
Vyacheslav Andreevich Vodolazhskiy
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Determination of the recreation potential of Kovada Lake National Park

Turkish Journal of Forestry
With the expansion of cities, the need for urban residents to connect with nature has increased. Individuals seeking to escape stress have begun to prefer green spaces such as nature reserves, forested areas, and urban parks.
Merve Nur Çağlayan
doaj   +1 more source