Results 211 to 220 of about 2,449,254 (296)

Case Report: rapid clinical complete response to Iparomlimab and Tuvonralimab combined with radiotherapy and chemotherapy in a patient with MSS/pMMR locally advanced rectal cancer. [PDF]

Front Oncol
Wang J, Yang T, Zhou J, Chen W, Wang G, Mei C, Chen Z, Li J, Shen T.   +8 more
europepmc   +1 more source

Predicting outcomes in equine peritonitis: Multivariable analysis of admission and post‐admission data from a UK hospital population

Equine Veterinary Journal, EarlyView.
Abstract Background Peritonitis is life‐threatening, and limited information exists regarding outcomes and predictors of survival. Objectives To report short‐ and long‐term outcomes in horses diagnosed with peritonitis and identify factors associated with survival. Study Design Retrospective observational. Methods Data were obtained for horses admitted
E. K. Kopec, H. Carslake, D. C. Archer, B. Morris, A. Wilson   +4 more
wiley   +1 more source

Single-Cell and Spatial Transcriptomics Across Populations With Perianal Fistulizing Crohn's Disease Shows Proinflammatory CD4⁺ Macrophage Involvement in Disease Progression. [PDF]

Cell Mol Gastroenterol Hepatol
Maddipatla SC, Munasinghe S, Dodd A, Tastad C, Moss R, Yin H, Murthy S, Dash A, Kolachala VL, Cutler DJ, Cho J, Kugathasan S, Matthews JD.   +12 more
europepmc   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Clinical Course, Laboratory Findings, and Tissue Distribution of Highly Pathogenic Avian Influenza A(H5N1) Virus in a Naturally Infected Domestic Cat. [PDF]

Viruses
Augustyniak A, Czyżewska-Dors E, Łagowski D, Domańska-Blicharz K, Lisowska A, Opolska J, Gogulski M, Pomorska-Mól M.   +7 more
europepmc   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

Temperature-dependent Persistence of African Swine Fever Virus. [PDF]

Int J Vet Sci Med
Kim DY, Kang YM, Kim YH, Kang HE, Yoo DS, Cho KH.   +5 more
europepmc   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

Diabetes Increases Immunotherapy‐Related Toxicity but Not Efficacy in Metastatic Non‐Small Cell Lung Cancer: A Multicenter Retrospective Study

International Journal of Cancer, EarlyView.
ABSTRACT This multicenter retrospective study evaluated the impact of type 2 diabetes mellitus (DM) on clinical outcomes and immune‐related adverse events (irAEs) in 450 patients with metastatic non‐small cell lung cancer (NSCLC) treated with second‐line nivolumab at 17 centers between 2016 and 2024. Among these patients, 118 (26.2%) had DM.
Emre Çakır, Didem Divriklioğlu, Deniz Can Güven, Gamze Serin Özel, Oğuzhan Yıldız, Gamze Emin, Merve Keskinkılıç, Yeşim Ağyol, Onur Yazdan Balçık, Nagihan Kolkıran, Hale Gülçin Yıldırım Doğan, Pervin Can Şancı, Özge Yalıcı, Teoman Şakalar, Yurdagül Danacı, Yakup Düzköprü, Canan Yıldız, Mesut Yılmaz, İlhan Hacıbekiroğlu, Bülent Erdoğan, Saadettin Kılıçkap, Gamze Gököz Doğu, Melek Karakurt Eryılmaz, Atila Yıldırım, İlhan Öztop, İbrahim Vedat Bayoğlu, Şahnura Uzuntaş, Atike Pınar Erdoğan, Emir Çelik, Devrim Çabuk, Erdoğan Selçuk Şeber, Zehra Sadak Öcal, Hacer Demir   +32 more
wiley   +1 more source

Reply to Gupta, "Reconsidering throat swab culture in melioidosis: diagnostic stewardship with clinical nuance". [PDF]

J Clin Microbiol
Duguid RC, Baird RW, Hennessy J, Currie BJ, Meumann EM.   +4 more
europepmc   +1 more source