Results 91 to 100 of about 104,894 (342)

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Large Friable Rectal Neuroendocrine Tumor Complicated by Hemorrhagic Shock: A Rare Case Report and Review of the Literature

JGH Open
Rectal neuroendocrine tumors (NETs) are rare neoplasms that are usually asymptomatic and diagnosed incidentally. There are limited data on the presentation and management of high‐grade poorly differentiated large friable rectal NETs.
Yazan Abboud, Imran Qureshi, Ayham Khrais, Alexander Le, Param Patel, Ozlem Fidan Ozbilgin, Sima Vossough‐Teehan   +6 more
doaj   +1 more source

Colorectal cancer screening: strategies to select populations with moderate risk for disease [PDF]

, 2015
Objective: to analyse the association between rectal bleeding or a family history of colorectal cancer (CRC) and the results obtained in two rounds of a CRC screening pilot programme performed in L'Hospitalet, Barcelona, Spain.
Binefa i Rodríguez, Gemma, Blanco Guillermo, Ignacio, Borràs Andrés, Josep Maria, Catalan Colorectal Cancer Screening Pilot Program Group, Espinàs Piñol, Josep Alfons, Guardiola, Jordi, Navarro, Matilde, Peris, Mercè   +7 more
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Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts [PDF]

, 2016
Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one sub-class, flavonols, was significantly associated with reduced risk of
Aedín Cassidy, Andrew T Chan, Arts, Bobe, Cassidy, Cassidy, Charles S Fuchs, Colditz, Cutler, DerSimonian, Devore, Edward L Giovannucci, Eric B Rimm, Feskanich, Fini, Gao, Giovannucci, Hirvonen, Hu, Jennifer H Lin, Kana Wu, Kandaswami, Katharina Nimptsch, Knekt, Knekt, Kyle, Lambert, Lee, Lin, Mahmoud, McCullough, Mingyang Song, Moon, Mursu, Park, Platz, Rich-Edwards, Rimm, Rossi, Rossi, Sacks, Salvini, Shuji Ogino, Simons, Stampfer, Theodoratou, Tobias Pischon, Voorrips, Walter C Willett, Wei, Willett, Willett, Willett, Williamson, Williamson, Woo, Xuehong Zhang, Yamauchi, Yang, Yu, Yuan, Zamora-Ros, Éilis J O’Reilly   +62 more
core   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Anorectal Malignant Melanoma Post- Hemorrhoidectomy

Acta Médica Portuguesa
Anorectal malignant melanoma, a rare and aggressive tumor, lacks specific symptoms and frequently presents diagnostic challenges due to its similarity to benign anorectal conditions.
Ramazan Kozan, Ozkan Akpinar, Meral Toker   +2 more
doaj   +1 more source

Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis [PDF]

Brazilian Journal of Nephrology
Introduction: Glomerular diseases can be associated with solid or hematopoietic malignancies. The prevalence of these associations varies according to the studied glomerular disease.
Marcella Soares Laferreira, Gianna Mastroianni Kirsztajn   +1 more
doaj   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Primary Leiomyosarcoma of Ovary [PDF]

, 2009
Primary ovarian leiomyosarcomas is a rare neoplasm which comprises less than 3% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure.
Kaul, R, Sharma, J
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