Results 101 to 110 of about 5,081,991 (350)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Diagnosis and Management of Rectal Neuroendocrine Tumors [PDF]

Clinical Endoscopy, 2017
The incidence of rectal neuroendocrine tumors (NETs) has increased by almost ten-fold over the past 30 years. There has been a heightened awareness of the malignant potential of rectal NETs. Fortunately, many rectal NETs are discovered at earlier stages due to colon cancer screening programs.
Shreya Chablaney, Zachary A. Zator, Nikhil A. Kumta   +2 more
openaire   +3 more sources

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

The role of rectal hyposensitivity in the development of functional hindgut disorders: clinical significance and pathophysiology [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorBackground Rectal hyposensitivity (RH) is associated with functional hindgut ...
Burgell, Rebecca Elizabeth
core   +2 more sources

Benefits & pitfalls of administration of rectal gel enema in MRI assessment of rectal cancer

The Egyptian Journal of Radiology and Nuclear Medicine, 2017
Objectives: To assess diagnostic benefits of filling of the rectum with ultrasound gel during MR assessment of rectal cancer and the pitfalls that occurs due to rectal distention.
Rafik Mohamed Ibrahim, Khalid Said
doaj   +1 more source

Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?

Clinical and Translational Radiation Oncology, 2020
Background and purpose: We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer.
Sebastian Meltzer, Kine Mari Bakke, Karina Lund Rød, Anne Negård, Kjersti Flatmark, Arne Mide Solbakken, Annette Torgunrud Kristensen, Anniken Jørlo Fuglestad, Christian Kersten, Svein Dueland, Therese Seierstad, Knut Håkon Hole, Lars Gustav Lyckander, Finn Ole Larsen, Jakob Vasehus Schou, Dawn Patrick Brown, Hanna Abrahamsson, Kathrine Røe Redalen, Anne Hansen Ree   +18 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Comparison of MRI and colonoscopy in determining tumor height in rectal cancer

United European Gastroenterology journal, 2017
Background and aim Endoscopy and magnetic resonance imaging (MRI) are used routinely in the diagnostic and preoperative work-up of rectal cancer. We aimed to compare colonoscopy and MRI in determining rectal tumor height.
L. Jacobs, D. Meek, J. van Heukelom, T. Bollen, P. Siersema, A. Smits, E. Tromp, M. Los, B. Weusten, N. van Lelyveld   +9 more
semanticscholar   +1 more source

Supplementary Table from Progression and Tumor Heterogeneity Analysis in Early Rectal Cancer

, 2008
Supplementary Table from Progression and Tumor Heterogeneity Analysis in Early Rectal ...
Eelco J.R. de Graaf (14975172), Tom van Wezel (24913), Tom Karsten (4733379), Rob A.E.M. Tollenaar (14908674), Jan Oosting (24912), Hans Morreau (66216), Esther H. Lips (9991320), Ronald van Eijk (160488), Pascal G. Doornebosch (9117963), Noel F.C.C. de Miranda (14892242), Paul H.C. Eilers (14898210)   +10 more
core   +1 more source