Results 21 to 30 of about 5,081,991 (350)

Development of a clinically-precise mouse model of rectal cancer. [PDF]

PLoS ONE, 2013
Currently-used rodent tumor models, including transgenic tumor models, or subcutaneously growing tumors in mice, do not sufficiently represent clinical cancer.
Hiroyuki Kishimoto, Masashi Momiyama, Ryoichi Aki, Hiroaki Kimura, Atsushi Suetsugu, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman   +7 more
doaj   +1 more source

Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers [PDF]

, 2013
Aim The study was carried out to investigate whether pretreatment haemoglobin (Hb) levels act as a biomar- ker in the management of patients with locally advanced rectal cancer.
Shabaan, A, Khan, AA, R. Glynne-Jones, Klonizakis, M, Glynne-Jones, R, A. A. Khan, M. Klonizakis, A. Shabaan   +7 more
core   +1 more source

Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer [PDF]

, 2013
Background: Preoperative radiochemotherapy (RCT) with 5-FU or capecitabine is the standard of care for patients with locally advanced rectal cancer (LARC). Preoperative RCT achieves pathological complete response rates (pCR) of 10-15%.
Erik Engel, Engel, Erik, Jürgen Dunst, Florian Würschmidt, Kathrin Dellas, Arnold, Dirk, Dirk Arnold, Michael Richter, Richter, Michael, Rödel, Claus, Thomas Reese, Höhler, Thomas, Thomas Höhler, Claus Rödel, Dellas, Kathrin, Reese, Thomas, Wagner, Wolfgang, Dunst, Jürgen, Würschmidt, Florian, Wolfgang Wagner   +19 more
core   +1 more source

Tumor Microenvironment before and after Chemoradiation in Locally Advanced Rectal Cancer: Beyond PD-L1

, 2022
Background: In locally advanced rectal cancer treatment, neoadjuvant concurrent chemoradiation therapy (cCRT) is the standard of care. The tumor microenvironment (TME) is a complex entity comprising of tumor cells, immune cells and surrounding stroma and
Ashten N. Omstead, Andrew J. Friday, Prashant Jani, Ping Zheng, Pritam Tayshetye, Gene Finley, Tanvi Verma, Stacey Miller, Ali Zaidi   +8 more
core   +1 more source

Feasibility and morbidity of combined hyperthermia and radiochemotherapy in recurrent rectal cancer - Preliminary results [PDF]

, 2003
Background: The local recurrence rate of colorectal cancer has been significantly reduced due to the use of combined radiochemotherapy. Despite this improvement regarding locally advanced tumour recurrences, the treatment strategy for pre-treated ...
Schaffer, P.M., Ertl-Wagner, Birgit, M. Schaffer, E. Dühmke, P.M. Schaffer, R.D. Issels, Pachmann, S., Abdel-Rahman, Sultan, S. Abdel-Rahman, Abdel-Rahman, S., Ertl-Wagner, B., Krych, M., Issels, Rolf-Dieter, Dühmke, E., B. Ertl-Wagner, Schaffer, Pamela Manuela, M. Krych, S. Pachmann, Schäffer, M., Issels, R.D., Dühmke, Eckhart, Schaffer, Moshe   +21 more
core   +1 more source

Association of levels of metabolites with the safe margin of rectal cancer surgery: a metabolomics study

BMC Cancer, 2022
Background Rectal cancer is one of the most lethal of gastrointestinal malignancies. Metabonomics has gradually developed as a convenient, inexpensive and non-destructive technique for the study of cancers.
Shaopeng Zhang, Guoqiang Pan, Zhifeng Liu, Yuan Kong, Daguang Wang   +4 more
doaj   +1 more source

Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer

Frontiers in Immunology, 2021
ObjectiveThis study aimed to characterize the tumor-infiltrating T cells in moderately differentiated colorectal cancer.MethodsUsing single-cell RNA sequencing data of isolated 1632 T cells from tumor tissue and 1252 T cells from the peripheral blood of ...
Xi Yang, Quan Qi, Yuefen Pan, Qing Zhou, Yinhang Wu, Jing Zhuang, Jiamin Xu, Mingyue Pan, Shuwen Han   +8 more
doaj   +1 more source

MRI-Diagnosed Tumor Deposits and EMVI Status Have Superior Prognostic Accuracy to Current Clinical TNM Staging in Rectal Cancer

Annals of Surgery, 2020
Summary Background Data: MRI assessment of rectal cancer not only assesses tumor depth and surgical resectability but also extramural disease which affects prognosis.
A. Lord, N. D'Souza, A. Shaw, Z. Rokan, B. Moran, M. Abulafi, S. Rasheed, A. Chandramohan, A. Corr, I. Chau, Gina Brown   +10 more
semanticscholar   +1 more source

Laparoscopic Versus Conventional Open Rectum Amputation: a Clinical, Intraoperative, and Short-term Outcome Comparative Study

Journal of Interdisciplinary Medicine, 2018
Objective: To evaluate and compare laparoscopic and conventional open rectum amputation procedures using clinical, intraoperative, postoperative, and oncological criteria.
Élthes Előd Etele, Cozlea Alexandra Lavinia, Török Árpád   +2 more
doaj   +1 more source

Anorectal Malignant Melanomas: Experience of Uludag University

Kaohsiung Journal of Medical Sciences, 2010
Anorectal melanomas represent a group of mucosal melanomas with unknown etiology and poor prognosis. The lesions can be misdiagnosed as hemorrhoids during clinical examination. We reviewed the morphological and clinical features of 14 anorectal melanomas,
Berna Aytac, Saduman Balaban Adim, Omer Yerci, Tuncay Yilmazlar   +3 more
doaj   +1 more source